摘要
目的探讨持续床旁肾替代疗法在重症胰腺炎患者中的应用及对炎症因子的影响研究。方法将我院2016年7月～2018年7月收治的78例重症胰腺炎患者分为对照组跟研究组。对照组进行常规治疗,研究组在常规治疗基础上给予持续床旁肾替代疗法进行治疗。对比两组患者临床治疗效果及预后状况、炎症因子水平、各项肾功能指标水平及急性生理健康状况。结果研究组患者临床疗效及预后状况均优于对照组(P <0. 05);治疗前两组患者炎症因子水平不具可比性差异(P> 0. 05),经治疗,研究组各炎性因子指标水平更优于对照组(P <0. 05);治疗前两组患者的各肾功能指标水平无可比性意义(P> 0. 05),治疗后研究组患者各肾功能指标水平与对照组相比更优(P <0. 05);两组患者急性生理健康状况造治疗前无异(P> 0. 05),治疗后研究组患者急性生理健康状况优于对照组(P <0. 05)。结论重症胰腺炎患者治疗过程中应用持续床旁肾替代疗法,可有效清除患者机体炎症介质,改善肾功能水平,提升患者预后,临床疗效显著,值得推广。
Objective To explore the application of continuous bedside renal replacement therapy in patients with severe pan- creatitis and its effect on inflammatory factors.Methods a total of 78 patients with severe pancreatitis who were admitted to our hospital from July 2016 to July 2018 were divided into the control group and the study group.The control group received conventional treatment and the study group was treated with continuous bedside renal replacement therapy on the basis of conventional treatment.The clinical therapeutic effect,prognosis,inflammatory factors,renal function indexes and acute physiological health of the two groups were compared.Results the clinical efficacy and prognosis of the study group were better than that of the control group (P <0.05).There was no comparable difference in the levels of inflammatory factors between the two groups before treatment (P >0.05 ).Mter treatment,the levels of inflammatory factors in the study group were better than those in the control group (P <0.05 ).The level of each renal function index in the two groups before treatment was not comparable (P >0.05),and the level of each renal function index in the study group after treatment was better than that of the control group (P .<0.05 ).The acute physiological health status of the two groups was the same before treatment (P >0.05),and the acute physiological health status of the study group was better than that of the control group after treatment (P <0.05).Conclusion continuous bedside renal replacement therapy can effectively remove inflammatory mediators in patients with severe pancreatitis,improve renal function,and improve prognosis of the patients.
作者
王晓波
WANG Xiao-bo(The First Affiliated Hospital of Anhui Medical University ,Hefei 230022,China)
出处
《肝胆外科杂志》
2018年第6期426-429,共4页
Journal of Hepatobiliary Surgery
关键词
持续床旁肾替代疗法
重症胰腺炎
应用
炎症因子
影响
研究
continuous bedside renal replacement therapy
severe pancreatitis
application
inflammatory factors
influence
research
