摘要
目的探讨尿酸(Uric Acid,UA)、甘油三酯(triglyceride,TG)、低密度脂蛋白(Low Density Lipoprotein,LDL)水平在脑卒中合并阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)患者中的变化及其临床意义。方法选取2016年1月-2018年1月在本院神经内科住院部收治的脑卒中患者354例作为研究对象,按照是否合并OSAHS将患者分为OSAHS组(n=85)与非OSAHS组(n=269);按照多导睡眠(Polysomnography,PSG)监测的暂停低通气指数(Apnea Hypopnea Index,AHI)不同将OSAHS组患者分为轻中度OSAHS亚组(AHI<50次/h,n=37),重度OSAHS亚组(AHI≥50次/h,n=48);根据PSG监测的夜间最低血氧饱和度(lowest oxygen saturation,L-SaO2)不同将OSAHS组患者分为轻中度低氧亚组(L-SaO2>70%,n=41)与重度低氧亚组(L-SaO2≤70%,n=44);采用酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)检测血清UA、TG、LDL水平。结果 OSAHS组UA、TG、LDL水平明显高于非OSAHS组(P<0.05)。轻中度OSAHS亚组UA、TG、LDL水平明显低于重度OSAHS亚组(P<0.05);轻中度低氧亚组UA、TG、LDL水平明显低于重度低氧亚组(P<0.05)。结论 OSAHS所致的呼吸暂停/低通气频度与低氧血症严重影响脑卒中患者UA与血脂代谢功能,通过监测UA、TG、LDL水平在评价OSAHS严重程度中具有重要意义。
Objective To study the changes and its clinical significance of Uric Acid (UA),triglycerides (TG),Low Density Lipoprotein (LDL) levels in stroke patients with obstructive sleep apnea and hypopnea syndrome (OSAHS).Methods 354 cases of stroke patients admitted in neurology inpatient department of our hospital from January 2016 to January 2018 were selected as the research object,according to whether combined OSAHS,all patients were divided into OSAHS group (n=85) and non-OSAHS group (n=269).According to Polysomnography (PSG) monitoring differences of Apnea Hypopnea Index (AHI),OSAHS group were divided into mild-to-moderate OSAHS subgroup (AHI<50 times/h,n=37),severe OSAHS subgroup (AHI≥50 times/h,n=48).According to PSG monitoring differences of lowest oxygen saturation (L-SaO2),OSAHS group were divided into mild-to-moderate low oxygen subgroup(L-SaO2>70%,n=41)and severe low oxygen subgroup (L-SaO2≤70%,n=44).Serum UA,TG,LDL levels were detected by using enzymelinked immunosorbent assay (ELISA).Results UA,TG,LDL levels of OSAHS group were obviously higher than those of non-OSAHS group (P<0.05).UA,TG,LDL levels of mild-to-moderate OSAHS subgroup were significantly lower than those of the severe OSAHS subgroup (P<0.05).UA,TG,LDL levels of mild-to-moderate low oxygen subgroup were significantly lower than those of severe low oxygen subgroup,(P<0.05).ConclusionThe sleep apnea and hypoxemia caused by OSAHS seriously affected UA and blood lipid metabolism function,monitoring UA,TG,LDL levels had the vital significance in the severity evaluation of OSAHS.
作者
徐创新
Xu Chuangxin(Tongcheng People's Hospital,Tongcheng Hubei 437400)
出处
《卒中与神经疾病》
2018年第6期657-661,共5页
Stroke and Nervous Diseases
