摘要
DNA甲基化研究的是基因在核苷酸序列不变的情况下DNA发生的天然修饰。目前,DNA甲基化在生物医药领域运用集中在研究疾病全基因组DNA甲基化的特点、规律以及寻找疾病的DNA甲基化生物标记物。本文在系统综述DNA甲基化研究技术的基础上,归纳和分析了DNA甲基化技术在中医证候生物学基础研究中运用的现状,提出了从全基因组DNA甲基化作为切入点来筛选中医证候生物标志物的建议。
DNA methylation studies the natural modification of DNA that occurs when the nucleotide sequence is unchanged. At present, DNA methylation is used in the field of biomedicine to focus on the characteristics and regularity of disease-wide genome methylation and the DNA methylation biomarkers for disease. Based on the systematic review of DNA methylation research techniques, this paper summarizes and analyzes the current status of DNA methylation technology in basic research of TCM(traditional Chinese medicine) syndromes, and a suggestion to screen the TCM syndrome biomarkers from whole genome DNA methylation is proposed.
作者
李晓娟
邱文琪
刘玥芸
吴佳佳
严志祎
侯雅静
陈家旭
Li Xiaojuan;Qiu Wenqi;Liu Yueyun;Wu Jiajia;Yan Zhiwei;Hou Yanjing;Chen Jiaxu(School of Traditional Chinese Medicine,Jinan University,Guangzhou 510632,China;School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2018年第11期1984-1988,共5页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金面上资助项目(81473597)肝郁脾虚型抑郁症海马-杏仁核神经活性甾体变化及逍遥散的作用机理
负责人:陈家旭
国家自然科学基金委重点基金项目(81630104):基于证候病机的逍遥散-肝郁脾虚证方证相关的生物学基础研究
负责人:陈家旭
国家自然科学基金委青年基金项目(81503496):基于扎根理论和内容分析法的肝郁证候定性和定量研究
负责人:薛飞飞
关键词
DNA甲基化
中医证候
DNA methylation
traditional Chinese medicine syndromes
