摘要
目的探讨D-二聚体和纤维蛋白(原)降解产物(FDPs)联合检测在血栓性疾病临床诊断中的应用价值。方法选取2016年1月—2017年12月在广安市中医医院住院治疗的血栓性疾病患者(血栓性疾病组)和非血栓性疾病患者(非血栓性疾病组)作为研究对象,每组55例。采集两组患者的血液标本,应用免疫比浊法检测血清D-二聚体和FDPs,比较两组患者的检测结果以及血栓性疾病组患者血清D-二聚体、FDPs单一阳性检出率和联合阳性检出率。结果血栓性疾病组患者的血清D-二聚体、FDPs均明显高于非血栓性疾病组[D-二聚体(mg/L):0.92±0.14比0.51±0.10,FDPs(mg/L):53.90±4.15比29.85±4.07,均P<0.05];血栓性疾病组患者的血清D-二聚体单一阳性检出率(65.45%比87.27%)和FDPs单一阳性检出率(60.00%比87.27%)均明显低于联合检测组(均P<0.05)。结论血清D-二聚体和FDPs升高与血栓性疾病的发生存在明显相关性,两者联合检测用于诊断血栓性疾病的准确性更高,有利于降低血栓性疾病的漏诊率和误诊率。
Objective To explore the application value of combined detection of D-dimer and fibrin degradation products(FDPs) in the clinical diagnosis of thrombotic diseases. Methods Patients with thrombotic disease(thrombotic disease group) and non-thrombotic disease patients(non-thrombotic disease group) who were hospitalized in Guang’an City Chinese Medicine Hospital from January 2016 to December 2017 were selected as the study subjects, with 55 cases in each group. Detection of serum D-dimer and FDPs by immunoturbidimetry in blood samples from two groups of patients. The detection results of serum D-dimer and FDPs in the thrombotic diseases group were compared to those of non-thrombotic diseases group, and the serum D-dimer, FDPs respective single positive rate was compared with the corresponding combined positive rates in patients with thrombotic diseases. Results Compared with the non-thrombotic disease group, the levels of serum D-dimer and FDPs were significantly higher than those in thrombotic disease group [D-dimer(mg/L): 0.92±0.14 vs. 0.51±0.10, FDPs(mg/L): 53.90±4.15 vs. 29.85±4.07, all P < 0.05]. Compared with the combined detection, the single positive rates of serum D-dimer(65.45% vs. 87.27%) and FDPs(60.00% vs. 87.27%) in patients with thrombotic diseases were respectively significantly low(P < 0.05). Conclusion The increase of serum D-dimer and FDPs is significantly correlated with the occurrence of thrombotic diseases, and the accuracy of the combined detection of serum D-dimer and FDPs is higher than any single one detection of them, so as the combined detection is helpful to reduce the rate of missed diagnosis and misdiagnosis of thrombotic diseases.
作者
彭超
文一波
Peng Chao;Wen Yibo(Department of Laboratory,Guang'an City Chinese Medicine Hospital,Guang'an 638000, Sichuan,China;Department of Internal Medicine,Guang'an City Chinese Medicine Hospital,Guang'an 638000,Sichuan,China)
出处
《实用检验医师杂志》
2018年第4期223-225,共3页
Chinese Journal of Clinical Pathologist
