摘要
目的:观察石斛明目丸联合西药治疗非增生期糖尿病视网膜病变肝肾亏虚、目络失养证的疗效。方法:筛选100例非增生期糖尿病视网膜病变肝肾亏虚、目络失养证患者,按随机数字表法分为治疗组和对照组,每组50例。2组均予常规干预措施、羟苯磺酸钙胶囊、胰激肽原酶肠溶片治疗,治疗组加服石斛明目丸,2组连续治疗3月。观察2组治疗前后肝肾亏虚、目络失养证症状评分与视力、眼压及眼底情况的变化,比较2组的临床疗效。结果:治疗组总有效率为88.0%,高于对照组的总有效率68.0%(P <0.05)。2组肝肾亏虚、目络失养证症状(视物模糊、目睛干涩、头晕、腰膝酸软、大便干结)评分均较治疗前下降(P <0.01);治疗组各项评分均低于对照组(P <0.01)。2组视力均较治疗前升高(P <0.01),治疗组眼压较治疗前下降(P <0.01);治疗组视力高于对照组(P <0.01),眼压低于对照组(P <0.01)。2组血管渗漏面积、微血管瘤个数以及毛细血管无灌注区面积均较治疗前减少(P <0.01),视网膜循环时间均较治疗前缩短(P <0.01);治疗组血管渗漏面积、微血管瘤个数以及毛细血管无灌注区面积均少于对照组(P <0.01),视网膜循环时间短于对照组(P <0.01)。结论:在常规西医疗法基础上加用石斛明目丸治疗非增生期糖尿病视网膜病变肝肾亏虚、目络失养证,可明显改善患者的视力和眼底循环障碍,提高临床疗效。
Objective:To observe the curative effect of Shihu Mingmu pills combined with western medicine for diabetic retinopathy in non-proliferative phase with syndromes of liver and kidney deficiency and denutrition of ocular collaterals.Methods:Screened 100 cases of patients with diabetic retinopathy in non-proliferative phase with syndromes of liver and kidney deficiency and denutrition of ocular collaterals and divided them into the treatment group and the control group according to random number table,50 cases in each group. Two groups were given routine intervention measures and were treated with calcium hydroxyl benzenesulfonate capsules and pancreatic kininogenase enteric-coated tablets, and the treatment group was additionally treated with Shihu Mingmu pills. The treatment for both groups continuously lasted for 3 months. Observed the changes of the symptom scores of syndromes of liver and kidney deficiency and denutrition of ocular collaterals,visual acuity,intraocular pressure and ocular fundus before and after treatment,compared the clinical effects in the two groups. Results:The total effective rate was 88.0% in the treatment group,being higher than that of 68.0% the control group(P < 0.05). The scores of syndromes of liver and kidney deficiency and denutrition of ocular collaterals(blurred vision, dry eyes, dizziness, soreness and weakness of waist and knees, dry and hard stool) in the two groups were deceased when compared with those before treatment(P < 0.01);each score in the treatment group was lower than that in the control group(P < 0.01). The visual acuity in the two groups was increased when compared with that before treatment(P <0.01). The intraocular pressure in the treatment group was deceased when compared with those before treatment(P < 0.01).The visual acuity in the treatment group was higher than that in the control group(P < 0.01),and the intraocular pressure was lower than that in the control group(P < 0.01). The vascular leakage area,retinal circulation time,number of microangiomas and capillary non-perfusion area in the two groups were declined when compared with those before treatment(P < 0.01). Thevascular leakage area,retinal circulation time,number of microangiomas and capillary non-perfusion area in the treatment group were less than that in the control group(P < 0.01). Conclusion:The additional application of Shihu Mingmu pills for patients with diabetic retinopathy in non-proliferative phase with syndromes of liver and kidney deficiency and denutrition of ocular collaterals on the basis of routine western medicine can significantly improve the visual acuity and circulatory dysorder of ocular fundus and promote clinical effect.
出处
《新中医》
CAS
2019年第1期100-103,共4页
New Chinese Medicine
关键词
糖尿病视网膜病变
非增生期
肝肾亏虚证
石斛明目丸
视力
眼压
Diabetic retinopathy
Non-proliferative phase
Liver and kidney deficiency syndrome
Shihu Mingmu pills
Visual acuity
Intraocular pressure
