摘要
目的:观察中西医结合治疗2型糖尿病合并非酒精性脂肪肝的疗效。方法:选取86例湿热瘀阻型2型糖尿病合并非酒精性脂肪肝患者作为研究对象,依据随机数字表法分为对照组和观察组各43例。2组患者均接受科学饮食、运动及健康教育等常规干预措施,同期给予格列吡嗪控释片,对照组口服盐酸二甲双胍片,观察组服用清热祛湿汤。2组患者均连续治疗3月。观察并比较2组的临床疗效、不良反应发生情况以及治疗前后血糖指标[糖化血红蛋白(HbA1c)、空腹血糖(FBG)、餐后2 h血糖(P2hBG)]、血脂指标[总胆固醇(TC)、甘油三酯(TG)]、肝功能指标[谷草转氨酶(AST)、谷丙转氨酶(ALT)、γ-谷氨酰转肽酶(γ-GT)]的变化情况。结果:治疗后,观察组总有效率93.02%,高于对照组的72.09%,差异有统计学意义(P <0.01)。2组血糖指标、血脂指标与肝功能指标值均较治疗前下降(P <0.01,P <0.05);观察组各指标值均低于对照组,差异均有统计学意义(P <0.01,P <0.05)。治疗期间,2组患者均未发生明显的药物不良反应。结论:在常规治疗基础上加服清热祛湿汤治疗湿热瘀阻型2型糖尿病合并非酒精性脂肪肝患者,可有效提高血糖控制效果,降低血脂水平,有利于肝功能的改善以及临床症状的缓解,疗效确切且安全性较高。
Objective:To observe the therapeutic effect of integrated Chinese and western medicine therapy for type 2 diabetes mellitus complicated with nonalcoholic fatty liver. Methods: Selected 86 cases of patients with type 2 diabetes mellitus complicated with nonalcoholic fatty liver of the damp-heat and blood-stasis obstruction type as study subjects,and divided them into the control group and the observation group according to the random number table method,43 cases in each group. Both groups received routine interventions such as healthy diet,exercise and healthy education,and Glipizide controlled-release tablets meanwhile. The control group was additionally treated with metformin hydrochloride tablets,while the observation group was additionally treated with Qingre Qushi tang. The two groups were treated continuously for three months. Observed and compared the clinical curative effect, adverse reactions and glycemic indexes including glycated hemoglobin A1 c(HbA1 c),fasting blood glucose(FBG) and 2 h postprandial glucose(P2 hBG),and blood-lipid indexes including total cholesterol(TC) and triglyceride(TG), as well as the liver-function indexes including aspertate aminotransferase(AST),alanine aminotransferase(ALT), and γ-glutamyl transpeptidase(γ-GT) in the two groups before and after the treatment.Results:After treatment,the total effective rate in the observation group was 93.02%,higher than that of 72.09% in the control group,the difference being significant(P < 0.01). The glycemic indexes,blood-lipid indexes and liver-function indexes in the two groups were decreased when compared with those before treatment(P < 0.01, P < 0.05). Each index in the observation group was lower than that in the control group,the difference being significant(P < 0.01,P < 0.05). No significant adverse drug reactions were observed in both groups during the treatment. Conclusion:The additional use of Qingre Qushi tang based on the routine treatment for patients with type 2 diabetes mellitus complicated with nonalcoholic fatty liver of the damp-heat and blood-stasis obstruction type,can effectively improve the control effect on blood glucose,reduce the levelof blood lipid,improve liver function and alleviate clinical symptoms,with significant therapeutic effect and high safety.
出处
《新中医》
CAS
2019年第1期104-107,共4页
New Chinese Medicine
关键词
2型糖尿病
非酒精性脂肪肝
湿热瘀阻证
中西医结合疗法
清热祛湿汤
肝功能
血糖
血脂
Type 2 diabetes mellitus
Nonalcoholic fatty liver
Syndrome of damp-heat and blood-stasis obstruction
Integrated Chinese and western medicine therapy
Qingre Qushi tang
Liver function
Glucose
Blood lipid
