摘要
目的:观察益气滋阴祛瘀法治疗狼疮性肾炎(LN)的疗效。方法:纳入55例阴虚内热、瘀血痹阻证的LN患者,随机分为治疗组29例和对照组26例。两组患者均给予西医常规治疗,在此基础上,治疗组患者给予益气滋阴祛瘀方口服,两组疗程均为3个月。评价并比较两组患者的中医证候评分、系统性红斑狼疮(SLE)疾病活动性指数(SLEDAI)评分;治疗前后检测患者的24 h尿蛋白定量、血沉(ESR)、C反应蛋白(CRP)及免疫球蛋白(Ig A、Ig G、Ig M)、补体(C3、C4)水平;治疗前后记录每个患者的激素使用情况,比较两组患者的激素撤减情况。结果:治疗后,两组患者的中医证候评分、SLEDAI评分均显著降低(P<0.01),且治疗组患者的评分均低于对照组(P<0.05)。治疗后,治疗组患者的24 h尿蛋白定量显著减少(P<0.01),且治疗组患者的24 h尿蛋白定量水平低于对照组(P<0.05)。两组患者治疗前后的ESR、CRP水平比较,差异均无统计学意义(P>0.05)。治疗前后,两组患者的lg A、lg G、lg M及补体C3、C4水平比较,差异均无统计学意义(P>0.05)。治疗后,治疗组患者的激素撤减率为58.62%,对照组为29.62%,治疗组的激素撤减率高于对照组(P<0.05);治疗组患者的激素使用剂量明显减少(P<0.05),对照组患者的激素使用剂量与治疗前比较差异无统计学意义(P>0.05)。结论:益气滋阴祛瘀方治疗阴虚内热、瘀血痹阻证LN患者,可明显改善患者的临床症状,降低其尿蛋白水平,并具有良好的辅助撤减激素作用。
Objective: To observe the efficacy of therapy of benefiting qi,nourishing yin and removing blood stasis in the treatment of lupus nephritis( LN). Methods: Fifty-five LN patients with syndrome of endogenous heat due to yin deficiency and stagnation of blood stasis were included and randomly divided into the treatment group( 29 cases) and the control group( 26 cases). The patients in both groups were treated with conventional western medicine,and the patients in the treatment group were orally treated with prescription of benefiting qi,nourishing yin and removing blood stasis based on above therapy,with a course of 3 months. The Chinese medical syndrome score and the systemic lupus erythematosus disease activity index( SLEDAI) score were evaluated and compared. Before and after treatment,the levels of 24 h urinary protein,erythrocyte sedimentation rate( ESR),C-reactive protein( CRP),immunoglobulin( Ig A,Ig G and Ig M) and complement( C3 and C4) were detected. Before and after treatment,the usage of hormone in each patient was recorded,and the hormone withdrawal in the two groups were compared. Results: After treatment,the scores of Chinese medical syndrome and SLEDAI were obviously decreased in both groups( P<0.01),and the scores of the treatment group were lower than those of the control group( P<0.05). After treatment,the level of 24 h urinary protein in the treatment group was significantly decreased( P<0.01),and the level of 24 h urinary protein in the treatment group was lower than that in the control group( P<0.05). In both groups,there were no statistically significant differences on the levels of ESR and CRP between treatment before and after( P>0.05). In both groups,there were no statistical differences on the levels of Ig A,Ig G,Ig M and complement C3 andC4 between treatment before and after( P>0.05).After treatment,the hormone withdrawal rates of the treatment group and the control group were 58.62% and 29.62% respectively,and the hormone withdrawal rate of the treatment group was higher than that of the control group( P<0.05);the hormone dosage in the treatment group was obviously decreased( P<0.05),but in the control group,there was no statistically significant difference on the hormone dosage between treatment before and after( P>0.05). Conclusion: Prescription of benefiting qi,nourishing yin and removing blood stasis can improve the clinical symptoms,reduce the level of urinary protein in treating LN patients with syndrome of endogenous heat due to yin deficiency and stagnation of blood stasis,and it also helps to hormone withdrawal.
作者
杨晔颖
苏励
YANG Yeying;SU Li(Department of Rheumatology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)
出处
《上海中医药大学学报》
CAS
2019年第1期32-35,共4页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
国家"十一五"科技支撑计划资助项目(2006BA104A10)
关键词
狼疮性肾炎
益气滋阴祛瘀法
中西医结合疗法
lupus nephritis
therapy of benefiting qi,nourishing yin and removing blood stasis
therapy of integrated Chinese and western medicine
