摘要
目的观察粉尘螨滴剂舌下含服治疗小儿过敏性哮喘的临床效果。方法选择沈阳市儿童医院2016年6月—2017年6月收治的新确诊的过敏性哮喘患儿130例,随机分为对照组和观察组各65例。两组患儿在哮喘急性发作期均接受全球哮喘防治创议(GINA方案)常规治疗,观察组在此基础上给予粉尘螨滴剂舌下含服,总治疗周期1年,比较两组的免疫学和肺功能指标。结果两组治疗前,粉尘螨特异性水平、螨过敏血清水平、嗜酸细胞阳离子蛋白水平差异均无统计学意义(P>0.05)。两组治疗后,上述指标均明显下降,与同组治疗前相比差异有统计学意义(P<0.05);且组间差异有统计学意义(P<0.05)。两组治疗前,用力肺活量、第1秒末用力呼气量、呼气峰流速水平差异均无统计学意义(P>0.05)。两组治疗后,上述指标均明显升高,与同组治疗前相比差异有统计学意义(P<0.05);且组间差异有统计学意义(P<0.05)。结论采用粉尘螨滴剂治疗小儿过敏性哮喘,有利于调节免疫状态,改善肺功能,值得临床推广应用。
Objective To observe the clinical effect of sublingual administration of Dermatophagoides Farinae Drops in treatment of allergic asthma in children.Methods A toal of 130 newly diagnosed children with allergic asthma in our hospital from June 2016 to June 2017 were randomly divided into control group and observation group,65 cases in each group.Both groups received GINA routine treatment during acute attack of asthma.The observation group was given sublingual administration of dermatophagoides farinae drops for a total treatment period of I year.The immunological and pulmonary function indexes of the two groups were compared.Results There was no significant difference in the levels of total IgE(TIgE),specific IgG4(SIgG4)and eosinophil cationic protein(ECP)between the two groups before treatment(P>0.05).After treatment,the above indicators were significantly decreased in both groups(P<0.05),while there was a significant difference between the two groups(P<0.05).There was no significant differences in the levels of force vital capacity(FVC),forced vital capacity in 1 second(FEV1.0)and peak expiratory flow(PEF)between the two groups before treatment(/9>0.05).After treatment,the above indicators were significantly increased in both groups(P<0.05),while there was a significant difference between the two groups(P<0.05).Conclusion The dermatophagoides farinae drops is helpful to regulate immune status and improve pulmonary function in the treatment of allergic asthma in children,which is worthy of clinical application.
作者
郝亮亮
HAO Liangliang(No.5Internal Medicine,Shenyang Children's Hospital,Shenyang,110032,Liaoning Province,China)
出处
《中国实用乡村医生杂志》
2019年第2期60-62,共3页
Chinese Practical Journal of Rural Doctor
关键词
哮喘
过敏性
粉尘螨滴剂
免疫治疗
特异性
小儿
舌下含服
Asthma
Allergic
Dermatophagoides Farinae Drops
Immunotherapy
Specificity
Children
Sublingual
