摘要
心血管疾病(cardiovascular disease,CVD)是目前危害人类生命健康的最重要的疾病,其中以冠心病(coronrayheart disease,CHD)为甚。微小RNA(microRNA、miRNA)是一类在转录后水平调控基因表达及功能的小分子非编码RNA,参与多种疾病的病理生理过程。微小RNA-223(miR-223)是一种髓系特异性miRNA,在血小板、血浆、内皮细胞中含量丰富,可通过调控血小板及内皮细胞的多种基因表达及功能,参与CVD发生发展,如动脉粥样硬化、血栓形成,心肌代谢,血管生成等多个环节。本文就miR-223在CVD中的作用做一综述。
Cardiovascular disease is one of the most important diseases that endanger people's life,and coronary heart disease is the most prevalent worldwide.MicroRNAs are a class of small,noncoding RNAs regulating the expression and functions of target genes posttranscriptionally and participating in the pathophysiological process of various diseases.As a myeloid specific miRNA,MicroRNA-223 is abundant in platelets,plasma and endothelial cells,and is involved in the development of many cardiovascular diseases. The present investigation on miR-223 functions in cardiovascular diseases contributes to the understanding of the oathogenesis,diagnosis,treatment and prognosis of cardiovascular diseases.
作者
孙垭娉
张俊峰
SUN Ya-ping;ZHANG Jun-feng(Department of Cardiology,Shanghai Ninth People's Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 201999,China)
出处
《心脏杂志》
CAS
2019年第1期89-93,共5页
Chinese Heart Journal
基金
上海市自然科学基金项目资助(16ZR1419900)
