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非甾体消炎药物临床应用不良反应的相关分析 被引量:14

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摘要 目的分析非甾体消炎药物临床应用不良反应的相关。方法选取医院收治的类风湿性关节炎、骨关节炎疾病患者180例,随机分为甲、乙、丙3组,每组60例。甲组予布洛芬治疗,乙组予双氯芬酸钠治疗,丙组予美洛昔康治疗,比较3组患者消化道不良反应发生率、心血管事件发生率情况。结果消化道不良反应发生情况甲组>乙组>丙组。3组患者在不稳定型心绞痛、非ST段抬高型心肌梗死、急性心肌梗死等心血管发生率方面两两比较差异均无统计学意义(P> 0. 05)。结论相较于非选择性COX-2抑制剂,选择性COX-2抑制剂不良反应发生率更低,临床当中可根据患者实际情况,在排除了禁忌证的基础上以选择性COX-2抑制剂作为非甾体类抗炎药应用首选。
出处 《临床合理用药杂志》 2019年第2期93-94,共2页 Chinese Journal of Clinical Rational Drug Use
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