摘要
目的分析老年社区获得性肺炎呼吸衰竭患者凝血功能的变化与临床意义。方法将2013年12月—2017年9月收治的老年社区获得性肺炎患者48例作为研究对象,以患者是否合并呼吸衰竭为依据,将其分为A、B两组,其中A组患者未合并呼吸衰竭,28例; B组患者合并呼吸衰竭,20例;再选取同时期健康志愿者50名作为对照组,检测3组研究对象凝血功能指标,包括血小板计数(PLT)、D-二聚体(D-D)、纤维蛋白原(FIB)、部分活化凝血酶原时间(APTT)、外周血凝血酶原时间(PT);并对比A、B两组患者的CURB-65评分与动脉血氧分压(PaO_2)水平。结果与对照组、A组对比,B组患者PT、D-D、APTT指标水平更高,PLT、FIB水平更低,差异均有统计学意义(P<0.05);与A组对比,B组PaO_2水平更低,CURB-65评分更高,差异均有统计学意义(P<0.05); CURB-65评分和D-D、APTT、PT之间为正相关,PaO_2水平和D-D、APTT、PT之间为负相关(P<0.05)。结论老年社区获得性肺炎患者有凝血功能异常现象存在,当其合并呼吸衰竭时表现得尤为明显,且凝血功能指标和患者病情严重程度之间具有明显相关性。
Objective To studied the clinical significance of changes in coagulation function of elderly patients with community-acquired pneumonia complicated with respiratory failure.Methods Forty-eight elderly patients with community-acquired pneumonia admitted from December 2013 to September 2017 were included in the study.The patients were divided into group A and B based on whether they were combined with respiratory failure.The 28 cases of patients without respiratory failure were in group A,and the other 20 cases combined with respiratory failure were in group B.50 healthy volunteers in the same period were selected as the control group,the coagulation function indicators of the three groups were tested,including platelet count( PLT),D-dimer( DD),fibrinogen( FIB),partial activation prothrombin time( APTT),peripheral blood prothrombin time( PT).The differences of CURB-65 score and arterial oxygen partial pressure( PaO2) level between groups A and B were compared.Results Compared with the control group and the A group,the PT,DD,and APTT levels were higher in the B group,and the PLT and FIB levels were lower,the differences were statistically significant( P<0.05).Compared with the A group,the PaO2 level in the B group was lower,CURB-65 score was higher,the differences were statistically significant( P<0.05).CURB-65 score was positively correlated with DD,APTT and PT,and PaO2 level was negatively correlated with DD,APTT and PT( P<0.05).Conclusions Coagulation dysfunction is present in elderly patients with community-acquired pneumonia,especially when they were complicated with respiratory failure,and there is a significant correlation between coagulation function indicators and the severity of the patient’s condition.
作者
古辉
黄国华
陈少立
彭昌
GU Hui(Respiratory medicine department,people's hospital of Gaoming district,Foshan,Guangdong 528500,China)
出处
《齐齐哈尔医学院学报》
2018年第19期2284-2286,共3页
Journal of Qiqihar Medical University
关键词
社区获得性肺炎
老年人
呼吸衰竭
凝血功能
临床意义
Community acquired pneumonia
Elderly
Respiratory failure
Coagulation
Clinical significance
