摘要
目的 探讨CT引导125I粒子植入联合吉西他滨+顺铂(GP)治疗非小细胞肺癌(NSCLC)的临床疗效。 方法 将2013年1月至2017年1月间62例Ⅱb~Ⅲb期不可切除的NSCLC患者按照随机数字表法分成2组,研究组[32例;男17例,女15例;年龄(62.7±8.9)岁]行125I粒子植入联合GP方案4个疗程化疗,对照组[30例;男18例,女12例;年龄(61.9±7.0)岁]行同步放疗联合GP方案4个疗程化疗。对比分析2组患者治疗3和6个月后的近期疗效,并对生存时间进行比较。采用log-rank检验分析数据。 结果 研究组和对照组治疗3和6个月后有效率分别为90.62%(29/32)、70.00%(21/30)和96.88%(31/32)、66.67%(20/30),差异均有统计学意义(χ^2值:3.00和7.22,均P<0.05);2组患者的中位生存时间分别为17和15个月(χ^2=2.194,P>0.05)。研究组与对照组患者的1年生存率未见明显差异[87.50%(28/32)和76.67%(23/30);χ^2=1.24,P>0.05];2年生存率的差异有统计学意义[40.62%(13/32)和20.00%(6/30);χ^2=4.00,P<0.05]。 结论 125I粒子植入联合GP方案化疗治疗不可切除NSCLC的近期疗效优于同步放疗联合GP方案。
Objective To investigate the clinical efficacy of CT-guided 125I seeds implantation combined with gemcitabine + cis-platinum (GP) in the treatment of unresectable non-small cell lung cancer (NSCLC). Methods From January 2013 to January 2017, 62 patients with unresectable Ⅱb-Ⅲb NSCLC were randomly divided into 2 groups. In the study group, 32 patients (17 males, 15 females, age (62.7±8.9) years) underwent 125I seeds implantation combined with 4 courses of GP chemotherapy, and 30 patients (18 males, 12 females, age (61.9±7.0) years) in the control group underwent concurrent radiotherapy combined with 4 courses of GP chemotherapy. The short-term effects at 3 and 6 months after treatment were compared between 2 groups, as well as the survival time. Log-rank test was used to analyze the data.Results The effective rates at 3 and 6 months after treatment in the study group and control group were statistically significant (90.62%(29/32) vs 70.00%(21/30), 96.88%(31/32) vs 66.67%(20/30);χ^2 values: 3.00 and 7.22, both P<0.05). The median survival time of the study group and control group were 17 and 15 months (χ^2=2.194, P>0.05). The 1-year survival rates of 2 groups were 87.50%(28/32) and 76.67%(23/30), respectively (χ^2=1.24, P>0.05), and the 2-year survival rates were 40.62%(13/32) and 20.00%(6/30), respectively (χ^2=4.00, P<0.05). Conclusions 125I seeds implantation combined with GP chemotherapy is a significant treatment for unresectable NSCLC. The short-term efficacy is better than concurrent radiotherapy combined with GP regimen.
作者
邹佳丽
陆武
陈鹏
宋长祥
刘永
袁小帅
杜鹏
Zou Jiali;Lu Wu;Chen Peng;Song Changxiang;Liu Yong;Yuan Xiaoshuai;Du Peng
出处
《中华核医学与分子影像杂志》
CAS
北大核心
2019年第2期96-99,共4页
Chinese Journal of Nuclear Medicine and Molecular Imaging
基金
江苏省人力资源与社会保障厅“六大人才高峰”资助项目(2013-WSW-012).
