摘要
为了探讨强化护理管理对于减轻食管癌放化疗患者毒副反应的临床价值,本研究在2017年1月至2017年4月选取我院接受放化疗治疗的130例食管癌患者,所有患者均接受三维适形放疗(3D-CRT)并同步化疗,其中65例患者化疗过程中采用强化护理管理措施(研究组),另外65例患者仅采取一般护理措施(对照组)。通过对比分析两组毒副反应的严重程度、KPS评分和生存质量的差异,结果显示:研究组的恶心呕吐、放射性食管炎、放射性肺炎发生率均显著低于对照组(p<0.05);研究组和对照组的腹泻、白细胞减少、脱发、周围神经炎的严重程度差异无统计学意义(p>0.05);治疗前,两组患者的KPS评分差异无统计学意义(p>0.05);治疗3周、治疗后6周,研究组的KPS评分均高于同期对照组(p<0.05);治疗前,两组患者的躯体功能、躯体角色、情感角色、机体疼痛、一般健康状况、心理健康、社会功能、活力评分差异无统计学意义(p>0.05);治疗后,研究组的躯体功能、躯体角色、情感角色、机体疼痛、一般健康状况、心理健康、社会功能、活力评分均高于同期对照组(p<0.05)。综上所述,加强护理管理对于减轻食管癌放化疗患者毒副反应具有重要的临床价值。
In order to explore the cl inical value of intensive nursing management to reduce the side effects of radiotherapy and chemotherapy in patients with esophageal cancer, in this research, a total of 130 esophageal cancer patients receiving chemoradiation therapy enrolled in our hospital were selected from January 2017 to April 2017.All patients underwent 3 D-CRT and chemoradiotherapy simultaneously. Among them, 65 patients were taken the intensive nursing management measures(study group), while the other 65 patients only took general nursing care(control group). The study compared the severity of adverse reactions, KPS score and quality of life between the two groups. The results showed that the incidences of nausea and vomiting, radiation esophagitis and radiation pneumonitis in the study group were significantly lower than those in the control group(p<0.05). There was no significant difference in the severity of diarrhea, leucopenia, hair loss and peripheral neuritis between the study group and the control group(p>0.05). Before treatment, there was no significant difference in KPS scores between the two groups(p>0.05). After 3 weeks of treatment and 6 weeks after treatment, KPS scores in the study group were significantly higher than those in the control group at the same period(p<0.05). Before treatment, there was no significant difference in somatic function, body role, emotional role, somatic pain, general health status, mental health, social function and vitality scores between the two groups(p>0.05);After treatment, the somatic function, body role, emotional role,somatic pain, general health status, mental health, social function and vitality scores in the study group were higher than those in the control group at the same period(p<0.05). In conclusion, strengthening nursing management has important clinical value in alleviating the side effects of radiotherapyand chemotherapyin patients with esophageal cancer.
作者
曹春美
马楚君
Cao Chunmei;Ma Chujun(The First Affiliated Hospital of Nanjing Medical University,Nanjing,210029)
出处
《基因组学与应用生物学》
CAS
CSCD
北大核心
2019年第2期821-826,共6页
Genomics and Applied Biology
关键词
强化护理
食管癌
三维适形放疗
化疗
毒副反应
Intensive care
Esophageal cancer
Three-dimensional conformal radiotherapy
Chemotherapy
Toxic side effects
