摘要
肠道微生物参与肠道内环境稳定、机体免疫应答、药物代谢和肿瘤发生等,与人类健康和疾病密切相关。肠道微生物紊乱可以引起多种疾病,近年来通过粪菌移植恢复肠道微生态平衡来治疗不同疾病得到了广泛关注,其最佳适应证是难治性和复发性难辨梭菌感染,但在其他领域包括血液系统疾病中的应用也在不断探索和验证,例如粪菌移植用于治疗造血干细胞移植后的肠道难辨梭菌感染、造血干细胞移植后肠道急性GVHD和免疫性血小板减少性紫癜等。本文将主要综述近年来粪菌移植的研究现状、操作程序及其在血液疾病中应用的最新研究进展。
Intestinal microbiome closely relates with human health and disease, which plays a critical role in the immune response, homeostasis, drug metabolism and tumorigenesis. Imbalances in the composition and function of these intestinal microbes associate with diseases. Fecal microbiota transplantation(FMT) is an established successful treatment modality for recurrent Clostridium difficile infection(CDI). The safety profile and potential therapeutic advantages of FMT for diseases associated with dysbiosis and immune dysfunction have led to many publications, mainly case series. The literature on the use of FMT for hematologic diseases is very limited, however, immune thrombocytopenic purpura(ITP), CDI and aGVHD after HSCT were reported to be improved by FMT. The aim of this review is to briefly summarize the research current state, procedures and clinical application of FMT.
作者
齐凌
李菲
QI Ling;Li Fei(Department of Hematology,The First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China;Institute of Hematology,Academy of Clinical Medicine Sciences of Jiangxi Province,Nanchang 330006,Jiangxi Province,China)
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2019年第1期306-310,共5页
Journal of Experimental Hematology
基金
国家自然科学基金(编号81560036
81560034)
江西省科技厅对外合作项目(编号20151BDH80043)
江西省卫计委科技计划(编号20175137
20171044)
关键词
肠道微生物
粪菌移植
造血干细胞移植
免疫性血小板减少性紫癜
intestinal microbiome
fecal microbiota transplantation
hematopoietic stem cell transplantation
immune thrombocytopenic purpura
