摘要
目的分析结构脂肪乳与中/长链脂肪乳对肝癌切除术后患者血脂、免疫细胞及急性炎症反应的影响。方法选取河南省人民医院(郑州大学人民医院)2013年1月至2017年3月60例行肝癌切除术患者,分为实验组(用结构脂肪乳)与对照组(用中/长链脂肪乳),各30例。输注脂肪乳前及输注第2、4、6、8天检测三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、T淋巴细胞、纤维蛋白原(FIB)、C反应蛋白(CRP)、前列腺素E2(PGE2)水平。结果输注前两组LDL-C、HDL-C、TG及TC差异无统计学意义(P>0.05)。肠外营养液输注第2天,两组血脂水平均较输注前升高。输注第4、6、8天,对照组LDL-C、HDL-C、TG及TC高于实验组,差异有统计学意义(P<0.05)。肠外营养输注后,两组CD3+、CD4+、CD8+、CD4+/CD8+水平均较输注前升高,且实验组高于对照组,差异有统计学意义(P<0.05)。与输注前比较,两组输注第2天FIB、CRP以及PGE2开始升高,差异有统计学意义(P<0.05)。第2、4、6、8天对照组CRP高于实验组,分别为(19.12±5.84)mg/ml比(13.76±2.36)mg/ml、(31.67±8.68)mg/ml比(17.21±2.66)mg/ml、(22.15±8.33)mg/ml比(12.48±0.63)mg/ml、(9.65±4.66)mg/ml比(7.52±0.99)mg/ml,PGE2也高于实验组,差异有统计学意义(P<0.05)。结论结构脂肪乳应用于肝癌切除术后患者,在改善血脂、免疫细胞以及炎症反应方面优于中/长链脂肪乳。
ObjectiveTo analyze the effects of structured fat emulsion and medium/long chain fat emulsion on blood lipids, immune cells and acute inflammation after hepatectomy for hepatocellular carcinoma.MethodsTotal of 60 patients with hepatocellular carcinoma who underwent hepatectomy in Henan People's Hospital (Zhengzhou University People's Hospital) from January 2013 to March 2017 were divided into experimental group (using structured fat emulsion) and control group (using medium/long chain fat emulsion), 30 cases in each group. Triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), total cholesterol (TC), T lymphocyte level, fibrinogen (FIB), C-reactive protein (CRP), prostaglandin E2 (PGE2) were detected before and 2, 4, 6 and 8 days after infusion.ResultsThere were no significant differences in LDL-C, HDL-C, TG and TC between the two groups before infusion (P>0.05). On the 2nd day of parenteral nutrition infusion, the level of blood lipids in both groups was higher than experimental group before infusion;on the 4th, 6th and 8th day of infusion, LDL-C, HDL-C, TG and TC in the control group were higher than those in the experimental group (P<0.05). After parenteral nutrition infusion, the levels of CD3+ , CD4+ , CD8+ , CD4+ /CD8+ in both groups were higher than experimental group before infusion, and the experimental group was higher than the control group, the differences were statistically significant (P<0.05). Compared with before infusion, level of FIB, CRP and PGE2 began to increase on the 2nd day of infusion, and the differences were statistically significant (P<0.05). On the 2nd, 4th, 6th and 8th day, CRP in the control group was higher than experimental group. And resepeatively (19.12±5.84) mg/ml vs. (13.76±2.36) mg/ml, (31.67±8.68) mg/ml vs. (17.21±2.66) mg/ml, (22.15±8.33) mg/ml vs. (12.48±0.63) mg/ml, (9.65±4.66) mg/ml vs. (7.52±0.99) mg/ml, and PGE2 were also higher than that in the experimental group (P<0.05). ConclusionStructured fat emulsion is superior to medium/long chain fat emulsion in improving blood lipid, immune cells and inflammatory reaction in patients after hepatectomy.
作者
蔡建平
周湘鸿
余海波
王亚东
薛焕洲
周炳喜
李德宇
Cai Jianping;Zhou Xianghong;Yu Haibo;Wang Yadong;Xue Huanzhou;Zhou Bingxi;Li Deyu(Department of Hepatobiliary and Pancreatic Surgery,Henan Province People's Hospital (Zhengzhou University People's Hospital),Zhengzhou 450005,China;Department of Cardiology,Henan Province People's Hospital (Zhengzhou University People's Hospital),Zhengzhou 450003,China;Department of Gastroenterology,Henan Province People's Hospital (Zhengzhou University People's Hospital),Zhengzhou 450003,China)
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2019年第1期18-21,共4页
Chinese Journal of Hepatobiliary Surgery
关键词
癌
肝细胞
脂肪乳剂
静脉注射用
脂质代谢
Carcinoma, hepatocellular
Fat emulsions, intravenous
Lipid metabolism
