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甘草酸对癫痫大鼠海马神经元损伤的保护作用及机制 被引量：8

Mechanism and protective effect of glycyrrhizic acid on hippocampus hippocampal neurons injury in epileptic rat models with epilepsy
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摘要 癫痫是一种临床上表现为反复性、刻板性、暂时性及发作性的脑部疾病[1-2]。我们构建癫痫大鼠模型,探讨甘草酸对癫痫大鼠海马神经元损伤的作用及其机制。一、材料与方法采用45只sD雄性大鼠氯化锂-匹鲁卡品点燃制作癫痫模型,大鼠麻醉后断头取脑组织,并在4℃条件下钝性分离大鼠双侧海马组织,在液氮罐中保存。
作者 郝泽林 卢晓东 王卫民 程军 孙佳桦 Hao Zelin;Lu Xiaodong;Wang Weimin;Cheng Jun;Sun Jiahua(Department of Neurosurgery, the Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China;Department of Neurology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China)
机构地区 杭州师范大学附属医院神经外科 杭州师范大学附属医院神经内科
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2019年第2期241-241,共1页 Chinese Journal of Experimental Surgery
基金 2017年浙江省医药卫生科技平台项目 (2017KY126).
关键词 海马神经元损伤 癫痫大鼠 甘草酸 保护作用 脑部疾病 大鼠模型 癫痫模型 匹鲁卡品
分类号 R742.1 [医药卫生—神经病学与精神病学]
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中华实验外科杂志
2019年 第2期

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