摘要
目的 :探讨急性脑梗死 (ACI)患者始发状态证候量值评分与内皮素 (ET)和胰岛激素的相关关系。方法 :1对 338例 ACI始发状态患者进行了中风辨证量化诊断调查 ;2采用放射免疫分析 (RIA)法检测 2 6 6例ACI患者血浆 ET、胰岛素 (INS)和胰高血糖素 (GL U)的变化 ;3分析评分与指标之间的相关关系 ,并与 30名正常健康人组作对照。结果 :1痰湿证量值与 ET含量关系最为密切 (r=0 .72 ,P<0 .0 1) ,其次为风证、火热证及血瘀证 (r=0 .38～ 0 .4 6 ,P均 <0 .0 1) ;2气虚证与阴虚阳亢证则无此变化 (r=0 .14～ 0 .16 ,P均 >0 .0 5 ) ;3各证候 ET水平与健康对照组比较 ,差异均非常显著 (P均 <0 .0 1) ;4风证、火热证、痰湿证及血瘀证量值评分与血浆 INS、GL U水平呈高度相关 (r=0 .33～ 0 .5 7,P均 <0 .0 1) ,与阴虚阳亢证呈显著性相关 (r=0 .2 1,P<0 .0 5 ) ;与气虚证无关 (r=0 .13,P>0 .0 5 ) ;5 ACI患者血中 INS及 GL U水平显著高于健康人组 (P均 <0 .0 1)。结论 :ET、INS和 GL U参与了 ACI中医证候的发生与发展过程 ,其变化特点与中医病因病机相符合 ,ET并成为 ACI的脑病理基础之一。
Objective:To study the relationship between traditional Chinese medicine(TCM) syndrome qrantitative volume and endothelin(ET),insular hormone in patients with acute cerebral infarction(ACI) in initial stage.Methods: ①Quantitative diagnosis of differential diagnosis in 338 patients with ACI during initial state were performed.②The levels of serum ET, insulin(INS) and glucogons(GLU) in 266 cases with ACI were determined by radioimmunal analysis (RIA),while 30 health subjects were taken as the control group.Results:①The quantitative volume of TCM phlegmdampness syndrome (痰湿证) were obviously positively related with level of ET ( r =0 72, P <0 01),and wind syndrome (风证),firehot syndrome (火热证) and blood stasis syndrome (血瘀证) were following ( r =0 38-0 46,all P <0 01).②Qideficiency syndrome (气虚症) and hyperactivity of Yang due to Yindificiency syndrome (阴虚阳亢证) were not related with ET levels( r =0 14-0 16 ,both P >0 05).③The ET levels of various TCM syndromes with ACI were higher than healthy control (all P <0 01).④The quantitative volume of TCM wind syndrome (风证),firehot syndrome (火热证),phlegmdampness syndrome (痰湿证) and blood stasis syndrome (血瘀证) were obviously positively related with levels of INS and GLU ( r =0 33-0 57,all P <0 01),and the quantitative volume of hyperactivity of Yang due to Yindificiency syndrome (阴虚阳亢证) were positively ralated with the levels of INS and GLU too ( r =0 21, P <0 05),but Qideficiency syndrome (气虚症) had no the relation ( r =0 13, P >0 05). ⑤The levels of INS and GLU in various TCM syndromes with ACI were higher than healthy control (all P <0 01 ).Conclusions:ET,INS and GLU participates the formation and development of TCM syndrome with ischemic storke.The pattern of change was in accordance with etiology and pathogenesis of TCM.ET may be one of the cerebral pathologic basis of ACI.
出处
《中国中西医结合急救杂志》
CAS
2002年第2期108-110,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
广东省珠海市医药卫生科研基金资助项目 (No.19995 410 )
关键词
急性脑梗死
辨证量化标准
内皮素
胰岛激素
相关性研究
acute cerebral infarction
quantitative standard of syndrome differentiation
endothelin
insular hormone
relativity study
