摘要
骨折愈合是一个复杂的生理过程,涉及多种细胞和细胞因子的协同作用。骨科医师很有必要了解骨折愈合中发生于细胞和分子水平的现象,探讨骨折不愈合及延迟愈合的机理,俾能采取针对性的措施以促进骨折愈合。骨折愈合从组织学上可分为血肿炎症期、初始骨痂反应期、软骨形成期及骨形成和改建期。细胞、细胞外基质蛋白及生长因子等在此过程中发生的变化是骨折愈合分子生物学的主要内容。最近研究发现Hedgehog(Hh)家族作为一种分泌蛋白和信号分子在脊椎动物发育和骨折愈合过程中起一定的作用。除骨组织本身外,神经组织及其所含神经肽也参与骨折愈合。
Fracture healing is a complex physiologic process that involves the coordinated participation of several cell types and cytokines. It is necessary for an orthopedic surgeon to grasp the phenomena occurring at cellular and molecular levels during fracture healing, which would enable him to explore the mechanisms of nonunion and delayed union and have good grounds to take measures directed at enhancing the healing process. Histologically fracture healing may arbitrarily be divided into four stages, ie, hematoma and inflammation, primary callus response, chondrogenesis, osteogenesis and bone remodeling, and the changes which incur on many types of cells, extracellular matrix and growth factors constitute the essential part of the molecular biology in fracture healing. Recently it has been found that Hedgehog family as a secreted protein and signaling molecule plays a major role in vertebrate development and bone healing. Apart from bone tissue in itself, the neural tissue and neuropeptides it contains also has a place in fracture healing.
出处
《当代医学》
2002年第1期27-32,共6页
Contemporary Medicine
关键词
骨折
愈合
分子生物学
fracture, healing, molecular biology
