摘要
目的：调查医院常见病原菌环丙沙星（ciprofloxacin,CIP)的耐药现状，为遏制细菌对其耐药性提供帮助。方法：分析1997－2000年住院患者标本中分离出的3800株病原菌对CIP药敏试验结果。结果：4年间金黄色葡萄球菌。表皮葡萄球菌和肠球菌避几种主要革兰阳性球菌，对环丙沙得的耐药率较高，且有逐渐上升的趋势，耐药率分别由1997年的50％，25．6％和40．3％，上升到2000年的62．2％，53．4％和63．6％。大肠埃希菌，肺炎克雷伯菌肠杆菌属对CIP的耐药率均在40％以上，铜绿假单胞菌和不动杆菌对其耐药率2000年分别达到31．1％和34．0％，2000年分离到的189株致医院感染菌中金黄色葡萄球菌，表皮葡萄球菌，肠球菌对CIP的耐药率均高达70％以上。结论：常见病原菌对CIP的耐药率较高，且4年间有逐渐上升之势，要严格限制此药的不合理应用。
Objective To obtain primary knowledge of drug resistance to ciprofloxacin in the common pathogenic bacteria in this hospital thereby to bring the situation under control. Methods A total of 3 800 strains of pathogenic bacteria were isolated from in-patients from 1997 to 2000, and drug resistance of these strains to ciprofloxacin was examined. Results During the past 4 years, Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis were found to be highly resistant to ciprofloxacin with the rates still on the rise from 50%, 25.6% and 40.3% in 1997 to 62.2%, 53.4% and 63.6% respectively in 2000. Over 40% of Escherichia coli, Klebsiella pneumoniae and Enterobacter were resistant to ciprofloxacin and the percentages for Pseudomonas aeruginosa and Acinetobacter reached 31.1% to 34.0% in 2000. Among the 189 strains of the pathogenic bacteria isolated from patients with sustained infection in our hospital in 2000, over 70% of Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis were identified as having resistance to ciprofloxacin. Conclusion The percentages of common pathogenic bacteria that are resistant to ciprofloxacin have been considerably high and tend to increase further. Ciprofloxacin abuse needs to be given appropriate attention.
出处
《第一军医大学学报》
CSCD
北大核心
2002年第4期378-379,共2页
Journal of First Military Medical University
关键词
细菌
耐药率
环丙沙星
pathogenic bacteria
antibiotic resistance
ciprofloxacin
