摘要
目的 研究茵陈蒿汤对地塞米松 (DX)致胰岛素抵抗 (insulinresistance ,IR)模型大鼠血糖、丙二醛 (MDA)含量和超氧化物歧化酶 (SOD)活性的影响。方法 以DX致IR、糖耐量减退 (IGT)模型大鼠分别ig药物或蒸馏水 (DW) qd× 7～ 8d ,测定其空腹血糖 (FBG)、口服葡萄糖 (1 0 g/kg)试验 (OGTT)后 2小时血糖 (2hBG)及给药后 2h空腹血清血糖 (FSG)、SOD活性和MDA浓度 ,并与格列齐特组对照。结果 茵陈蒿汤不影响病鼠FBG(P >0 .0 5) ,却能明显降低大鼠OGTT后 2hBG(P <0 0 1 ) ,改善地塞米松致IR模型大鼠的IGT。降低给药后 2hFSG(P <0 .0 1 ) ,但对MDA浓度和SOD活性均未见明显影响 (P>0 .0 5)。结论 茵陈蒿汤和格列齐特均可改善胰岛素抵抗 ,两药的作用机制可能有所不同。
Objective Effects of Yinchenhao decoction on improving insulin resistance in dexamethasone induced insulin resistant rats were investigated.Methods Fasting blood glucose,2-hours blood glucose (2hBG) after oral glucose (10g/kg) tolerance test(OGTT),fasting serum glucose(FSG),the content of malonaldehyde and superoxide dismutase activity by dexamethasone (DX)-induced impaired glucose tolerance(IGT) and insulin resistant(IR)-rats were studied.Results Yinchenhao decoction didn′t influence FBG( P >0.05) and was able to lower 2hBG( P <0.01) after OGTT and improve IGT in DX induced insulin resistant rats,lower FSG( P <0.01) and didn′t influence the content of MDA and SOD.Conclusion The results suggest that Yinchenhao decoction and gliclazide can improve dexamethasone induced insulin resistance,but both mechanism can be not the same.
出处
《广东药学》
2002年第2期46-48,共3页
Guangdong Pharmaceutical Journal
基金
广东省中医药局资助项目( 972 79)
关键词
茵陈蒿汤
地塞米松
胰岛素抵抗
丙二醛
超氧化物歧化酶
Yinchenhao decoction
dexamethasone
insulin resistance
malonaldehyde
superoxade dismutase
