摘要
目的 探讨孕三烯酮对卵巢子宫内膜异位症并发不孕的治疗疗效。方法 1 5例患者给予孕三烯酮 2 .5mg ,每周 2次 ,共 6个月。对其中少数患者加用利维爱 (HRT)治疗以减少用药并发症。停用孕三烯酮后 ,部分患者应用促排卵药物 ,1例采用宫腔内受精(IUI)。治疗前、后分别行B超、MRI、血清CA1 2 5、生殖激素 (FSH ,LH ,E2 )及骨密度 (BMD)的测定。结果 治疗后痛经等症状缓解。B超、MRI显示 :卵巢病灶明显减小占 2 /3。血清CA1 2 5、生殖激素 (FSH ,LH ,E2 )水平明显降低 (P <0 .0 1 )。腰椎骨密度 (L -BMD)无明显变化 (P >0 .0 5) ,妊娠率达 73 .3 %。结论 孕三烯酮保守治疗卵巢子宫内膜异位症并发不孕是一种有效的方法 。
Objective To study the effect of Gestrinone capsules on adenomyosis complicated with infertility. Methods Gestrinone capsules were given to 15 patients suffering from adenomyosis complicated with infertility with a dosage of 2.5mg twice a week for 6 months. To some patients, additional Lival (HRT treatment) was applied to reduce drug complications. After withdrawing the Gestrinone, assisted reproductive drugs were used for some patients and IUI was applied to one patient. Examinations of B-ultrasonography, MRI, L-BMD, Blood CA125 and sexual hormone were performed before and after the treatment. Results After the treatment, the symptoms of dysmenorrhea were relieved. B-us and MRI showed that the focus of adenomyosis and the volume and size of ovum diminished in 2/3. The levels of Blood CA125, FSH, LH and E2 decreased significantly (P<0.01). L-BMD had no significant changes (P>0.05). The pregnant rate reached 73.3%. Conclusion Gestrinone capsules are effective for the treatment of infertility with adenomyosis. ART and IUI are considered necessary to further improve the pregnant rate.
出处
《中国煤炭工业医学杂志》
2002年第4期320-322,共3页
Chinese Journal of Coal Industry Medicine
