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孤儿核受体类固醇生成因子1 被引量:1

Orphan Nuclear Receptor Steroidogenic Factor 1
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摘要 孤儿核受体是核受体超家族中较独特的成员 ,它参与了糖类、脂类及胆固醇和类固醇激素的代谢 ,可能是体内细胞基本功能的重要调节因子。孤儿核受体SF 1最初作为肾上腺和性腺中的P4 5 0羟化酶必需的调节子而被鉴定 ,在类固醇组织、垂体和下丘脑腹内侧核均有表达 ,SF 1在基因结构上具有不同于其他核受体的特征结构域 ,并广泛参与许多基因如类固醇合成酶类、M櫣llerian抑制性物质、黄体生成素 β亚基启动子等的表达调控 ,基因剔除实验证实SF
出处 《生命的化学》 CAS CSCD 2002年第2期115-118,共4页 Chemistry of Life
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参考文献13

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