摘要
目的 研究新型钙增敏强心剂 6 [4 (4′ 吡啶 )氨基苯 ] 4 ,5 二氢 3(2H)哒嗪酮 (MCI 15 4 )抗失血性休克效应并探讨其初步机理。方法 以改良Wigger法 ,即股动脉放血并维持血压 5 .33kPa 2h建立失血性休克动物模型 ,观察MCI 15 4对失血性休克大鼠 12、2 4和 4 8h存活率的影响 ;以彩色频谱多普勒观察MCI 15 4对失血性休克家兔心脏射血分数、每搏输出量及肝动脉、肠系膜上动脉、右肾动脉平均血流量和血流阻力指数的影响。结果 MCI 15 4组休克大鼠 12、2 4和 4 8h存活率分别为 17/ 2 0、15 / 2 0和13/ 2 0 ,明显高于生理盐水组的 11/ 2 0、8/ 2 0、4 / 2 0 ;MCI 15 4治疗后 2h ,能显著降低休克家兔肝、肾动脉血流阻力指数 ;治疗后 4h能明显增加休克家兔心脏射血分数、每搏输出量及肠系膜上动脉、肾动脉血流量 ,显著降低肝动脉血流阻力指数。结论 MCI 15 4有较满意的抗失血性休克效应 ,其机理可能与增强休克动物心脏功能和增加主要器官血流量有关。
AIM To explore the therapeutic effects of 6-[4-(4′-pyridyl) aminophenyl]-4,5-dihydro-3(2H)-pyridazinone (MCI-154), a novel calcium sensitizer for cardiac contraction, on hemorrhagic shock and its mechanism. METHODS The hemorrhage shock was established by bloodletting from femoral artery and keeping mean artery pressure at 5.33 kPa for 2 h, then normal saline (NS) or MCI-154 (0.2 mg·kg -1 for rabbits, 2.5 mg·kg -1 for rats) was given iv. The survival rate of rats at 12, 24 and 48 h, and heart′s ejection fraction(EF), stroke volume(SV), vascular resistance index(RI), blood flow volume of liver artery, mesentery artery and right kidney artery of rabbits were examinated by colorful Doppler. RESULTS The survival rate of rats in MCI-154 and NS groups at 12, 24 and 48 h was 17/20, 15/20, 13/20 , and 11/20, 8/20, 4/20, respectively. In hemorrhagic shock rabbits, MCI-154 decreased remarkably RI of kidney and liver arteries at 2 h after treatment, and increased significantly EF, SV, blood volume of mesentery artery and kindey artery, meanwhile decreased RI of liver artery at 4 h after treatment. CONCLUSION MCI-154 has satisfied therapeutic effect on hemorrhagic shock, which maybe related to its positive inotropic effect for cardiac function and increasing blood flow volume.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2002年第2期102-105,共4页
Chinese Journal of Pharmacology and Toxicology
基金
军队"九五"指令课题(96L041)
