摘要
目的 :对铁钉菜进行化学成分研究。方法 :采用稻瘟霉模型生物活性追踪方法 ,应用多种色谱技术进行分离 ,根据理化性质和波谱数据鉴定其结构。结果 :分离并鉴定了 7个化合物 :(2S) 1 O 十六碳酰基 2 O (11Z 十八碳烯酰基 ) 3 O β D 吡喃半乳糖基甘油 (I) ,(2S) 1 O 十六碳酰基 2 O 十四碳酰基 3 O (6 ' 硫代 α D 脱氧吡喃葡萄糖基 )甘油 (Ⅱ ) ,(2S) 1 O 十六碳酰基 2 O 十六碳酰基 3 O (6 ' 硫代 α D 脱氧吡喃葡萄糖基 )甘油 (Ⅲ ) ,(2S) 1 O 十六碳酰基 2 O (11Z 十八碳烯酰基 ) 3 O (6 ' 硫代 α D 脱氧吡喃葡萄糖基 )甘油 (Ⅳ ) ,硬脂酸 (V) ,肉豆蔻酸甲酯 (Ⅵ )和棕榈酸 (Ⅶ )。结论 :I～Ⅵ系首次从铁钉菜中得到 ;I,Ⅱ ,Ⅳ为新天然产物 ,I～Ⅳ具有诱导稻瘟霉菌丝变形活性和较弱的肿瘤细胞毒活性。
Objective: To study the chemical constituents of Ishige okamurai .Method: Compounds were isolated by Pyricularia oryzae bioassay guided fractionation method in combination with extraction and partitionation as well as multi chromatography. Their structures were determined by spectral analysis and chemical evidence. Result:Seven compounds were obtained and identified as (2 S) 1 O palmitoyl 2 O (11Z octadecenoyl) 3 O β D galacto pyranosyl glycerol (I), (2 S) 1 O palmitoyl 2 O myristoyl 3 O (6' sulfo α D quinovopyranosyl) glycerol (Ⅱ), (2 S) 1 O palmitoyl 2 O palmitoyl 3 O (6' sulfo α D quinovopyranosyl)glycerol (Ⅲ) and (2 S) 1 O palmitoyl 2 O (11Z octadecenoyl) 3 O (6' sulfo α D quinovopyranosyl) glycerol (Ⅳ), stearic acid (V), methyl myristate(Ⅵ) and palmitic acid (Ⅶ). Conclusion: Compounds I～Ⅵ were isolated from the alga for the first time while I, Ⅱ and Ⅳ are new natural products. I～Ⅳ showed activity causing morphological abnormality of P. oryzae mycelia.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2002年第4期269-273,共5页
China Journal of Chinese Materia Medica
