摘要
目的 观察高活性心钠素 (haANP)治疗充血性心力衰竭 (CHF)的疗效及心钠素 (ANP)与超氧化物岐化酶 (SOD)的关系。方法 选择符合CHF诊断标准的连续住院患者 110例 ,随机分为haANP治疗观察组 79例 ,给予haANP 30 0 μg加入5 %葡萄糖 2 5 0ml中静滴 ;常规治疗对照 31例 ,疗程均为 14d。观察治疗疗效及治疗前后心率、心胸比、血压、左心室舒张末内径 (LVDd)、左心室射血分数 (LVEF) ,检测治疗前后SOD和ANP水平。结果 观察组总有效率 81% ,与对照组 5 1.6 %比较有显著性差异 (P <0 .0 1) ,观察组治疗后心率、血压、心胸比、SOD、LVDd均明显下降 (P <0 .0 5、P <0 .0 1) ,LVEF增加 (P <0 .0 1)。结论 haANP治疗CHF疗效显著 ,SOD与病情缓解有关 。
Objective To evaluate the effectiveness of high activity atrial natriuretic polypeptide(haANP) in treatment of patients with congestive heart failure(CHF) and its relationship with blood superoxide dismutase level.Methods 110 consecntively hospitalized patients who fulfilled the diagnostic criteria of CHF were randomized into haANP group(n=79) and control group(n=31).Control group received conventional therapy,and haANP group received haANP 300 μg per day besides conventional therapy.At 14th day after treatment,curative effects were observed.Heart rate,cardiothoracic ratio,blood pressure,left ventricular end distolic diameter(LVDd),left ventricular ejection fraction(LVEF),concentration of blood superoxide dismutase(SOD) and haANP were assayed before and after the treatment.Results There was a significant difference in effective ratio between the haANP group and the control group (P<0.05),which was 81.0% against 51.6%,respectively.The heart rate,caridothorcic ratio,blood pressure,LVDd,LVEF,and concentration of blood superoxide dismutase(SOD) were significantly decreased in the haANP group,compared with the control group.Conclusions HaANP has a significant therapeutic effect on patients with congestive heart failure;it decreases blood SOD level which is related to the severity of heart failure
出处
《武警医学》
CAS
2002年第4期199-202,共4页
Medical Journal of the Chinese People's Armed Police Force
关键词
高活性心钠素
充血性心力衰竭
超氧化物歧化酶
自由基
治疗
High activity atrial natriuretic polypeptide Congestive heart failure Superoxide dismutase Free radicals
