摘要
目的 :研制卡铂肺靶向微球。方法 :用乳化法制备卡铂微球 ,正交试验设计考察影响制备工艺的因素 ,体外释药试验研究其缓释性 ,以微球在家兔的体内分布初步考察其靶向性。结果 :所制备微球 88.6%的粒径在 5～ 2 5μm,药物包封率为 79.2 % ,8小时体外药物累积释放百分率达 95 %并有良好的靶向性。结论 :用乳化法制备的卡铂肺靶向微球有良好的应用研究前景。
OBJECTIVE:To investigate gelatin microspheres loaded carboplatin ( C GMS) for lung targeting.METHOD: C GMS were prepared with the emulsifing method and some factors affecting the technology were analysed with the orthogonal test design. The sustained release of C GMS was studied through the delivery test in vitro. Lung targeting was tested preliminarily by the distribution of C GMS in different tissues in rabbits. RESULTS:The particle diameters of 88.6% C GMS were between 5 and 25 μm,drug encapsulated ratio was 79.2%, in vitro the drug cumulative release ratio during 8h was 95% and the C GMS had a good lung targeting.CONCLUSION:The C GMS for lung targeting prepared through the emulsifing method would have a good exploitation.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2002年第2期123-125,共3页
Chinese Journal of Modern Applied Pharmacy
