摘要
目的 :研究基质金属蛋白酶 1(MMP 1)和基质金属蛋白酶组织抑制剂 1(TIMP 1)在肺癌组织中表达及其临床生物学意义。方法 :常规石蜡包埋切片行SABC免疫组织化学检测 4 6例肺癌组织中MMP 1和TIMP 1的表达。结果 :4 6例肺癌和 15例正常肺组织中MMP1表达阳性的例数分别为 2 4例 (5 2 .2 % )和 3例 (2 0 % ) ,两者无相关性 ;TIMP1在正常肺组织和肺癌中的表达分别为 12例 (80 % )和 19例 (41.3% ) ,肺癌明显低于正常肺组织 ;MMP1和TIMP1在肺癌中表达与其分化程度、分期、淋巴结转移有明显相关性 ,且MMP1与TIMP1的表达呈明显负相关。结论 :MMP1和TIMP1蛋白的表达与肺癌的发生发展、生物学行为、侵袭和转移有关 。
Objective To investigate the expression of MMP1 and TIMP1 proteins in lung cancer tissues and its biological significance. Methods MMP1 and TIMP1 proteins were detected with the immunohistochemical method of avidin biotin complex in formalin fixed and routinely paraffin embeded specimens of 46 patients. Results There was no correlation in MMP1 protein expression between normal lung tissues (20%) and lung cancer (52.2%); The positive rate of TIMP1 protein expression was significantly lower in lung cancer (41.3%) than that in normal lung tissues (80%); There was a significant correlation among MMP1 and TIMP1 protein expression and differentiation,TNM stages, and lymph node metastases of lung cancer.There was a significant negative correlation between MMP1 and TIMP1 protein expressions in lung cancer. Conclusion There is a correlation between MMP1 and TIMP1 protein expressions in lung cancer and the invasion and metastasis of lung cancer.The factors may be used as important biological markers in lung cancer.
出处
《湖南医科大学学报》
CSCD
北大核心
2002年第2期159-161,共3页
Bulletin of Hunan Medical University
