摘要
【目的】探讨中药青风藤的单体生物碱提取物青藤碱的抗炎作用机理。[方法]应用体外酶反应实验体系,观察青藤碱对离体环氧化酶－１(ＣＯＸ－１)和ＣＯＸ－２纯酶活性的影响。[结果]一定浓度的青藤碱对ＣＯＸ－２所致前列腺素Ｅ２(ＰＧＥ２)合成表现出较强的抑制作用,且有良好的量效关系。[结论]提示青藤碱选择性抑制ＣＯＸ－２的活性,可能是其抗炎镇痛作用较强而胃肠副作用小的主要机制之一。
[Objective] To explore the anti - inflammatory mechanism of sinomenine, a monomer alkaloid from Caulis Sinomenii. [ Methods] In - vitro enzyme was applied to observe the effect of sinomenine on cyclooxygenase (COX) 1 and COX 2. [Results] Sinomenine at the concentration of 1 - 250 μmol/L could inhibit the formation of PGE2 induced by COX 2 in a good dose - effect manner. [Conclusion] Sinomenine selectively inhibiting the activity of COX 2 may be the anti - inflammatory and anagesic mechanism of sinomenine with less gastrointestinal adverse effect.
出处
《广州中医药大学学报》
CAS
2002年第1期46-47,51,共3页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
青藤碱
环氧化酶2
活性
选择性抑制作用
抗炎作用
药理学
CAULIS SINOMEN I/pharmacology
SINOMENINE /pharmacology
INFLAMMATION/TCD therapy
CYCLOOXYGENASE/antagonists and inhibitor
DEVOPROSTONE/antagonists and inhibitors
