1[1]Velazquez BM,Mendoza S,Hamer T,et al.Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia,insulin resistance,hyperandrogenemia,and systolic blood pressure,while facilitating normal menses and pregnancy[J].Metabolism,1994,43(5):647.
2[2]Dale PO,Tanbo T,Haug E,et al.The impact of insulin resistance on the outcome of ovulation induction with low-dose follicle stimulating hormone in women with polycystic ovary syndrome[J].Hum Reprod,1998,13(3):567.
3[3]Nestler JE,Jakubowicz DJ.Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome[J].N Engl J Med,1996,335(9):617.
4[4]Diamanti Kandarakia E,Kouli C,Tsianateli T,et al.Therapeutic effects of metformin on insulin resistance and hyperandrogenism in polycystic ovary syndrome[J].Eur J Endocrinol,1998,138(3):269.
5[5]Glueck CJ,Wang P,Fontaine R,et al.Metformin-induced resumption of normal menses in 39 of 43 (91%) previously amenorrheic women with the polycystic ovary syndrome[J].Metabolism,1999,48(4):511.
6[6]Kolodziejczyk B,Duleba AJ,Spaczynski RZ,et al.Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome[J].Fertil Steril,2000,73(6):1149.
7[7]Velazquez EM,Mendoza SG,Wang P,et al.Metformin therapy is associated with a decrease in plasma plasminogen activator inhibitor-1,lipoprotein(a),and immunoreactive insulin levels in patients with the polycystic ovary syndrome[J].Metabolism,1997,46(4):454.
8[8]Morin-Papunen LC,Koivunen RM,Ruokonen A,et al.Metformin therapy improves the menstrual pattern with minimal endocrine and metaboilc effects in women with polycystic ovary syndrome[J].Fertil Steril,1998,69(4):691.
9[9]Velazquez E,Acosta A,Mendoza SG.Menstrual cyclicity after metformin therapy in polycystic ovary syndrome[J].Obstet Gynecol,1997,90(3):392.
10[10]Nestler JE,Jakubowicz DJ,Evans WS,et al.Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome[J].N Engl J Med,1998,338(26):1876.
2The Rotterdam ESHRE/ASRM - Sponsored PCOS consensus work shop group. Revised 2003 consensus on diagnostic criteria and long- term health risks related to polycystic ovary syndrome (PCOS) [J]. Hum Reprod, 2004, 19 (1): 41.
3Marx TL, Mehta AE. Polycystic ovary syndrome: pathogenesis and treatment over the short and long term [J] . Cleve Clin J Med, 2003, 70:31-45.
4Laurel A, Benjamin C, Oehninger WS. Should patients with polycystic ovary syndrome be treated with metformin? Benefits of insulin sensitizing drugs in polycystic ovary syndromebeyond ovulation induce [J] . Human Reproduction, 2002, 17 : 3016 -3025.
5Marx TL, Mehta AE. Polycystic ovary syndrome: pathogenesis and treatment over the short and long term [J].. Cleve Clin J Med, 2003, 70:31-45.
6Tan S, Hahn S, Benson S, et al. Metform improves polycystic ovary syndrome symptoms irrespective of pre - treatment insulin resistance [J] .EurJEndocrinol, 2007, 157 (5): 669 -696.