摘要
目的 探讨雌激素调节蛋白PS2 在乳腺癌中的表达及其临床意义。方法 应用免疫组化S P法 ,对 4 8例人乳腺浸润性导管癌中PS2 进行检测 ,分析其与ER ,PR以及预后的关系。结果 PS2 与ER呈显著正相关。在ER(+)PR(+)的病人中 ,PS2 阳性率达 6 7 9% ,而在ER(- )PR(- )的病人中PS2 阳性率仅为 12 5 % ,二者相比有显著性差异 (P <0 .0 1)。PS2 阳性表达与病人长生存期呈正相关 ,与腋窝淋巴结转移无相关性。结论 在预测乳腺癌抗雌激素治疗的效果时 ,PS2 要优于ER ,PR。同时PS2 阳性的乳腺癌患者预后较好 ,PS2
Objective To investigate the clinical significance of the extrogen regulated protein PS 2 expression in breast cancer. Methods To study the relationship of the PS 2 to ER PR and prognosis, 48 cases of invasive ductal carcinoma of breast tissue slide were stained and detected by S P immunohistochemical method with the monoclonal antibody of PS 2. Results The positive rate of PS 2 was 67.9% in the patients with ER(+), PR(+). And it was 12.5% with ER(-) and PR(-)( P <0.01). The PS 2 expression was positively correlative with the expression of the ER and survival time of patients. Conclusion PS 2 is better than ER, PR to predict the curative effect of anti extrogen and it may serve as a indicator to predict the biological behaviors of breast cancer patients. The progrosis of patients with PS expression will be better.
出处
《临床军医杂志》
CAS
2002年第2期7-9,共3页
Clinical Journal of Medical Officers
