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血管内皮生长因子在子宫内膜异位症组织中的表达 被引量：2

Expression of vascular endothelial growth factor in tissues from endometriosis
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摘要 目的 :探讨血管内皮生长因子 ( VEGF)在子宫内膜异位症发生发展中的作用。方法 :采用免疫组织化学技术 ( LSAB法 ) ,分别检测 VEGF在子宫内膜异位症 ( 2 5例 )和非异位症 ( 2 5例 )患者子宫内膜组织中的表达。结果 :异位子宫内膜组织中 VEGF的阳性表达率为 72 % ,而非异位症的子宫内膜组织中无 VEGF表达。结论 :VEGF可能在子宫内膜异位症的发生。 Objective:To explory the role of vascular endoepithelial growth factor (VEGF) in the occurence and development of endometriosis.Methods:Expression of VEGF was examined in the specimens from 25 patients with endometriosis and the same patients without endometriosis (control) by immunohistochemical method.Results:Positive rate of expression of VEGF in tissues from endometriosis was 72%,while expression rate of VEGF in tissues from nonendometriosis was negative.Conclusion:The results indicated that VEGF might play an important role in the pathogenesis and development of endometriosis.
作者 邱晓红 高秀艳 李荷莲
机构地区 吉林大学第二医院妇产科
出处 《吉林大学学报（医学版）》 CAS CSCD 北大核心 2002年第2期147-148,共2页 Journal of Jilin University：Medicine Edition
关键词 血管内皮生长因子 表达 子宫内膜异位症 免疫组织化学 VEGF expression endometriosis
分类号 R711.71 [医药卫生—妇产科学] R392.11 [医药卫生—免疫学]
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参考文献7

  • 1谭先杰,郎景和.子宫内膜异位症的基础研究进展[J].中华妇产科杂志,1998,33(6):378-330. 被引量：38
  • 2Claren MJ,Prentice A,Chamck-Jones DS,et al.Vascular en dothelial growth factor (VEGF) concentrations are elevated in peritoneal fluid of woman with en dometriosis [J].Hum Re prod,1996,11: 220-223.
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二级参考文献2

  • 1顾玲芬，中华妇产科杂志，1996年，31卷，582页
  • 2令狐华，中华妇产科杂志，1996年，31卷，586页

共引文献37

同被引文献21

  • 1Ota H, Tanaka T. Stromal vascularization in the endometrium during adenomyosis[ J]. Microse Res Tech ,2003,60(4) :445
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  • 4Erdem O, Erdem M, Erdem A, et al. Expression of vascular endothelial growth factor and assessment of microvascular density with CD34 and endoglin in proliferative endometrium, endometrial hyperplasia, and endometrial carcinoma[J]. Int J Gynecol Cancer, 2007,17(6):1327
  • 5Khorram O, Lessey BA. Alterations in expression of endometrial endothelial nitric oxide synthase and alpha(v) beta ( 3 ) integrin in women with endometriosis [ J ]. Fertil Steril, 2002,78 (4) :860
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吉林大学学报（医学版）
2002年 第2期

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