摘要
合成了一种新型配体Bz-MAG 2(苯甲酰硫代乙酰基双甘氨肽),研究了该配体与^(99)Tc^m络合的影响因素(如反应体系pH值、反应温度和反应时间等),给出了络合产额≥98％的反应条件。在大白兔体内的显像结果表明:^(99)Tc^m-MAG_2的肾显像质量以及肾排泄速度都大大优于目前临床上常用的^(99)Tc^m肾显像剂^(99)Tc^m-DTPA(二乙撑三胺五乙酸),而稍次于^(99)Tc^m-MAG_3(巯基乙酰基三甘氨肽)。
Changing the length of peptide chain, a new ligand,B_2-MAG_2 (benzoylthioacetyl diglycine), was synthesized. The effects of the pH value, reaction temperature and reaction time on the formation of ^(99)Tc^m-MAGa were studied and the preparation procedure with the complexing yield up to 98％ was established. The results on rabbits showed that both imaging quality and excretion rate of ^(99)Tc^m-MAG_2 were more superior to those of ^(99)Tc^m-DTPA (diethylenetriamine pentaacetate) , which is currently used for renal imaging in clinic, while slightly inferior to ^(99)Tc^m-MAG_3 (mercaptoacetyl triglycine).
出处
《同位素》
CAS
北大核心
1991年第3期137-142,共6页
Journal of Isotopes
关键词
肾显像
显像剂
锝99
标记
放射性药物
renal imaging, ^(99)Tc^m-MAG_2, ^(99)Tc^m-MAG_3, ^(99)Te^m-DTPA.
