摘要
氨基酸序列的序列比对是研究蛋白的结构和功能关系的有力工具。本文利用Visual Basic for Applications的宏功能,采用Needleman-Wunsch算法在Excel中建立模型,对两条人类肿瘤抗体的氨基酸序列进行序列配联,找出它们的同源性。通过和一些常用序列分析软件的比较,这种方法简单、直观和易于接受。
Multiple Alignment of ammo acid sequence is a useful tool to study the relationship of the structure and function of proteins . In this article, a method of doing complete alignment to the search for similarities in the amino acid sequences of two human cancer antibody based on Needleman-Wunsch algorithm and carried out by Visual Basic for Applications of Excel. After comparing with other programs of alignment, the method is simple, visual and easy to take.
出处
《计算机与应用化学》
CAS
CSCD
北大核心
2002年第3期277-279,共3页
Computers and Applied Chemistry
