摘要
目的 应用多普勒超声心动图评价吲达帕胺和氢氯噻嗪对于轻中度原发性高血压病患者心脏结构和功能的影响。方法 63例轻中度高血压病患者随机双盲分为吲达帕胺组 (2 .5mg/d)、氢氯噻嗪组 (2 5mg/d)和未用药对照组。在用药前及用药后的 4周、6个月末行超声心动图检查评价心脏结构、左室功能。结果 两药均有逆转左室肥厚的趋势。 6个月后吲达帕胺组LVM和LVMI显著降低 ,LVMI从 (97.0 2± 15 .60 ) g/m2 降至 (73 .89± 16.70 ) g/m2 ,LVM从 (162 .75± 3 6.2 3 )g降至 (112 .7± 2 8.15 ) g ,P值分别 <0 .0 1和 <0 .0 5 ,与对照组比也显著降低 ,P <0 .0 1。 6个月时的LVMI和IVST在二药有显著性差异 ,P均 <0 .0 5。两药对舒张、收缩功能有改善趋势 ,氢氯噻嗪的作用稍强 ,但这些改变在与用药前和两药之间的比较中均无显著性意义。结论 吲达帕胺和氢氯噻嗪可轻度改善心脏收缩和舒张功能。吲达帕胺逆转左室肥厚的作用非常显著。
Objective To evaluate the effects of hydrochlorothiazide and indapamide on left ventricular structure and cardiac function in patients with mild to moderate primary hypertension. Methods The study was carried out in 63 patients with primary hypertension. Patients were randomly grouped to receive indapamide 2.5mg/d, HCTZ 25mg/d and nontreatment. Echocardiography was performed at baseline, after 4 week's and half a year's treatment. Results Echocardiography revealed a decrease in LV mass index (LVMI) and LVM in both treatment groups. In indapamide group, LVMI decreased from (97.02±15.60)g/m 2 to (73.89±16.70)g/m 2 ( P <0.01) and LVM decreased from (162.75±36.23)g to (112.7±28.15)g ( P <0.05). Small but no statistically significant improvement in left ventricular diastolic and systolic function were observed in both groups during the study. Conclusion It is concluded that both indapamide 2.5mg/d and HCTZ 25mg/d can slightly improve left ventricular function. Indapamide 2.5mg/d can significantly regress left ventricular hypertrophy in patients with mild to moderate hypertension.
出处
《中国医学影像技术》
CSCD
2002年第5期449-451,共3页
Chinese Journal of Medical Imaging Technology
关键词
超声心动图描记术
原发性高血压
氢氯噻嗪
吲达帕胺
左室结构
左室功能
Echocardiography
Primary hypertension
Hydrochlorothiazide
Indapamide
Left ventricular structure
Cardiac function
