摘要
为探讨Fas、Bax抗原的表达与狼疮性肾炎(lupusnephritis,LN)发病过程之间的关系,用免疫组化方法检测狼疮肾活检标本石蜡切片中Fas、Bax抗原的表达情况。狼疮性肾炎Bax抗原阳性表达率为70%,肾小管、肾小球、间质三个部位均有阳性表达;Fas抗原阳性表达率为75%,阳性表达仅见于肾小管;Fas、Bax阳性表达与LN病理分型间无明显的相关性(P>0.05)。促凋亡基因的过度表达,可能是狼疮性肾炎的发生、发展的重要因素。
To investigate the correlation between the expression of Fas and Bax antigens and morbidity of lupus nephritis, the expression of Fas and Bax antigens in paraffin section was studied with immunohistochemical technique. The positive expression of Bax antigen in lupus nephritis was 70%.There was a positive expression in glomerulus,uriniferous tubules and mesenchyme.The positive expression of Fas antigen was 75%, and was detected only in uriniferous .There was not a significant corelation between positive expression of Fas and Bax and pathological type in lupus nephritis(P >0.05). Over expression of apoptosis promoting gene probably play an important role in lupus nephritis.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2002年第5期282-283,共2页
Journal of Clinical Dermatology
