摘要
目的 : 比较国产丁咯地尔与己酮可可碱治疗急性脑梗死的疗效及安全性。方法 : 急性脑梗死患者10 2例 ,随机分为两组。治疗组 6 2例 ,用丁咯地尔 ,首剂 10 0mg ,次日 15 0mg ,以后均为 2 0 0mg ,分别溶于 2 5 0mL 0 .9%氯化钠注射液中 ,静脉滴注 ,qd。对照组 40例 ,用己酮可可碱 ,首日 10 0mg ,次日 2 0 0mg ,以后均为 30 0mg ,分别溶于 2 5 0mL0 .9%氯化钠注射液中 ,静脉滴注 ,qd。两组疗程均为 14d。结果 :治疗组与对照组的总有效率分别为 90 .3%和 92 .2 % ,经Ridit分析 ,差异无显著性 (P >0 .0 5 )。两者不良反应发生率分别为 11.3%和 10 .0 % ,均较轻 ,能耐受 ,经 χ2 检验 ,差异无显著性 (P >0 .0 5 )。结论 :丁咯地尔是治疗急性脑梗死安全有效的药物。
Objective:To evaluate the therapeutic effect and safety rate of domestic buflomedil and trental in the treatment of acute cerebral infarction(ACI). Methods:102 patients with acute cerebral infarction were randomly divided into 2 groups. For the 62 patients of the treatment group, a solution of 200 mg of buflomedil in 0.9% sodium chloride was used. The solution was administered by intravenous drip with an initial dose of 100 mg of buflomedil/case on the first day, 150 mg/case on the second day and 200 mg/case qd. beginning from the third day. Likewise, a solution of 300 mg of trental in 0.9% sodium chloride was prepared for the 40 patients of the control group. 100 mg of trental were given by intravenous drip to each patient of this group on the first day, 200 mg on the second day, followed by 300 mg q.d. beginning from the third day. The course of treatment in both groups lasted 14 days. Results:The total effective rates were 90.32% and 92.22% in the treatment group and control group, respectively, at the termination of the treatment. The difference was not significant statistically. The incidences of adverse reactions in the two groups were 11.3% and 10%, respectively. These reactions, however, were mild and tolerable. Conclusion:Buflomedil is an effective and safe remedy for the treatment of acute cerebral infarction.
出处
《医药导报》
CAS
2002年第5期283-285,共3页
Herald of Medicine
