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Caco-2细胞模型在口服药物吸收过程研究中的应用 被引量:30

Application of Caco-2 cell model in the study of oral drug absorption process
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摘要 目的 介绍Caco 2细胞模型的特点及其在口服给药吸收过程研究中的应用。方法 概括了近年来Caco 2细胞模型在口服药物开发中的应用情况和研究成果。结果 药物经Caco 2单层细胞转运情况的研究 ,可以预测药物在体内的吸收规律 ,为药物设计及制剂处方筛选提供科学依据。结论 Caco 2细胞模型是药物吸收过程研究的很好工具。
出处 《中国药学杂志》 CAS CSCD 北大核心 2002年第5期325-327,共3页 Chinese Pharmaceutical Journal
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  • 1Allen RH,Robert AC,Philip SB. Caco-2 cell monolayers as a model for drug transport across the intestinal mucosa[J].Pharm Res,1990,7(9):902.
  • 2Gan LL,Dhiren RT.Applications of the Caco-2 model in the design and development of orally active drugs:elucidation of biochemical and physical barriers posed by the intestinal epithelium[J].Adv Drug Deliv Rev,1997,23(1):77.
  • 3Hidalgo IJ,Raub TJ,Borchardt RT.Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability[J].Gastroenterology,1989,96(3):736.
  • 4Artursson P,Karlsson J.Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells[J].Bioche Biophy Res Commun,1991,175(3):880.
  • 5Yee S.In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man-fact or myth[J].Pharm Res,1997,14(6):763.
  • 6Hillgren KM,Kato A,Borchardt RT.In vitro systems for studying intestinal drug absorption[J].Med Res Rev,1995,15(1):83.
  • 7Liu DZ,Morris-Natschke SL,Kucera LS,et al.Structure-activity relationships for enhancement of paracellular permeability by 2-alkoxy-3-alkylamidopropylphosphocholines across Caco-2 cell monolayers[J].J Pharm Sci,1999,88(11):1169.
  • 8Jezyk N,Li C,Stewart BH,et al. Transport of pregabalin in rat intestine and Caco-2 monolayers[J].Pharm Res,1999,16(4):519.
  • 9Dimitrijevic D,Shaw AJ,Florence AT.Effects of some non-ionic surfactants on transepithelial permeability in Caco-2 cells[J].J Pharm Pharmacol,2000,52(2):157.
  • 10Lee K,Thakker DR.Saturable transport of H2-antagonists ranitidine and famotidine across Caco-2 cell monolayers[J].J Pharm Sci,1999,88(7):680.

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