摘要
心脏经历了短暂的心肌缺血再灌注后 ,对随后长时间缺血再灌注损失产生保护作用 ,这种现象称为缺血预处理 (预适应 )。预适应对心肌的保护作用主要表现在缩小心肌梗死范围、抗缺血再灌注性心律失常、改善心肌收缩和舒张功能等。研究表明 :心肌缺血预适应的机制可能与内源性心脏保护物质的释放、受体激活及信号传导有关。药理性预处理是根据缺血预处理机制 ,通过药物激发或模拟机体内源性物质的活性 ,进而呈现对心脏的保护作用。根据其作用机理的不同 ,将其分为特异性受体依赖性和非特异性受体依赖性 ,为研究防治心肌缺血性疾病提供了新思路。
Preconditioning the heart with a brief period of ischemia followed by reperfusion renders it very resistant to injury from a subsequent prolonged ischemic result.The protection by preconditioning has been described in dogs,pigs ,rats and rabbits,which lies in limiting infarct size,reducing the incidence of arrhythmia and improving postischemic ventricular recovery.Although little is known about the mechanisms afforded by ischemic preconditioning,stimulation of cardiac adenosine receptors,release of endogenous active substances and signal transduction pathway.Pharmacological preconditioning protection against heart injury is trigged by medicines which can mimic beneficial effects of cardiac ischamic preconditioning.According to mechanisms,these medicines can be classified into two kinds:specificreceptor-dependent and non-specific receptor-dependent like kinin receptor agonist and ATP-regulated potassium channel opener,which appears a novel access to treatment of cardiovascular diseases.
出处
《中国实验方剂学杂志》
CAS
2002年第3期60-64,共5页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
预适应
心肌缺血
研究进展
Ischemic preconditioning
Cardiac ischemia
