摘要
目的 :探讨原发性高血压、脑出血和脑梗塞急、慢性期血浆Na+ 、Mg2 + 及红细胞内Na+ 、Mg2 + 含量和Na+ /Mg2 + 交换率 ,以及与胰岛素抵抗和类洋地黄物质相关性。方法 :随机选择 78例患者分为原发性高血压组 (n =2 3)、脑出血组 (n =2 1)和脑梗塞组 (n =34) ,并选 2 0例健康查体者为对照组。采用原子吸收光谱火焰法测原发性高血压、脑出血、脑梗塞患者红细胞内Na+ 、Mg2 + 含量和Na+ /Mg2 +交换率〔钠 -镁外流最大速率 (VTmax)、非钠依赖性镁外流最大速率 (VNimax)、钠依赖性镁外流最大速率 (VNdmax)〕。同时测空腹血糖、血浆胰岛素和类洋地黄物质浓度。结果 :原发性高血压组血浆Na+ 、Mg2 + 与对照组相比无明显统计学差异 ,而原发性高血压组、脑出血组和脑梗塞组急、慢性期红细胞内Mg2 + 含量明显降低 ,VTmax、VNdmax明显增高 ,有显著性差异 (P均 <0 0 5 ) ,脑出血组、脑梗塞组急、慢性期红细胞内Na+ 含量则明显增高 (P <0 0 5～ 0 0 0 1) ,有显著性差异 ,红细胞内Mg2 + 含量、VNdmax与胰岛素抵抗和类洋地黄物质呈明显负相关 ,而红细胞内Na+ 含量与胰岛素抵抗和类洋地黄物质呈明显正相关。结论 :从以上结果可以看出原发性高血压和脑卒中患者由于红细胞内外Na+ /Mg2 + 转换率加快 。
Objective:To investigate the correlation between levels of plasma natrium(PNa),magnesium (PMg),erythrocyte natrium(ENC),magnesium (EMC),erthrocyte Na +/Mg 2+ exchange rate and endogenous digitalis-like substances (EDLS) versus insulin resistance (ISI)in patients with essential hypertension(EH),complicated by acute and chronic cerebral hemorrhage (CH) or cerebral infarction (CI). Methods:PNa,PMg,ENC,EMC and Na +/Mg 2+ exchange rate [maximum rates of total magnesium efflux (VTmax),sodium-independent magnesium efflux (VNImax),sodium-dependent magnesium efflux (VNdmax)] were measured by flame assay of atomic absorption spectropholometry.Plasma EDLS,fasting insulin and blood sugar were also determined. Results:PNa,PMg in EH group were not significantly different from those of the normal controls (p<0.05).EMC in EH,CH,CI was significantly reduced (p<0.05-0.001)and ENC was significantly elevated(p<0.01-0.001).VTmax and VNdmax in EH,CH,CI were higher than those of the controls (p<0.05-0.01).EMC and VNdmax were significantly negatively correlated with EDLS and ISI.ENC was significantly positively correlated with EDLS and ISI. Conclusion:The elevated erythrocyte Na +/Mg 2+ exchange rate in EH and stroke may be responsible for the decreased EMC and increased ENC.Also,ISI and EDLS may be involoed in and regnlated the process.
出处
《中国循环杂志》
CSCD
北大核心
2002年第2期105-108,共4页
Chinese Circulation Journal
基金
贵阳市自然科技基金资助 (1 998 1 4 0 8)
