摘要
为探讨肺内调节肽对支气管上皮细胞 (bronchialepithelialcells ,BECs)分泌功能的影响 ,实验观察了兔BECs在未受应激与臭氧应激两种条件下白细胞介素 (interleukin ,ILs)的分泌。结果发现 :血管活性肠肽 (vasoactiveintestinalpeptide ,VIP)对未受应激BECs存在抑制作用 ,并使臭氧应激BECs分泌ILs下降 ;表皮生长因子 (epidermalgrowthfactor,EGF)使未受应激BECsIL 1、IL 8分泌增加 ,使臭氧应激的BECsILs分泌降低 ;内皮素 1(endothelin 1,ET 1)、降钙素基因相关肽 (calcitoningene relatedpeptide ,CGRP)可使未受应激的BECs分泌ILs增加 ,CGRP还可使臭氧应激的BECsILs分泌增加。结果提示 :肺内调节肽可调控BECsILs的分泌 。
To explore the role of regulatory peptides in the secretion of bronchial epithelial cells (BECs), we observed the effects of four peptides, i.e.vasoactive intestinal peptide (VIP), epidermal growth factor (EGF), endothelin 1 (ET 1), and calcitonin gene related peptide (CGRP), on the secretion of ILs from unstimulated or O 3 stressed BECs. The results of the experiments showed that VIP exerted an inhibitory effect on the secretion of IL 1 and IL 8 from unstimulated and O 3 stressed BECs, VIP also decreased the secretion of IL 5 from O 3 stressed BECs; EGF promoted secretion of IL 1 and IL 8 from unstimulated BECs, but decreased the secretion of ILs from O 3 stressed BECs; ET 1 and CGRP enhanced the secretion of IL 1, IL 5, and IL 8 from unstimlated BECs, CGRP also increased the secretion of ILs from O 3 stressed BECs. The results obtained demonstrate that intrapulmonary regulatory peptides modulate the secretion of ILs from BECs, and may play an important part in transduction of inflammatory signals.
出处
《生理学报》
CAS
CSCD
北大核心
2002年第2期107-110,共4页
Acta Physiologica Sinica
基金
ThisworkwassupportedbytheNationalNaturalScienceFoundationofChina (No 3 9770 63 5
3 980 0 0 5 3 )
