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IGFBP-1在产科领域中的生理作用和应用 被引量:19

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摘要 近年类胰岛素生长因子结合蛋白1(IGFBP-1)在产科领域中的作用和应用逐渐被认识。血循环中的IGFBP-1主要由肝细胞产生,羊水中的IGFBP-1主要由蜕膜和胎儿组织产生,它主要通过抑制类胰岛素生长因子的活性发挥作用。胎盘中某些细胞因子可影响IGFBP-1的水平。胎盘母儿界面高浓度的IGFBP-1可抑制滋养层侵蚀蜕膜;孕期血循环中IGFBP-1持续升高会产生某些不良围产结局。临床可利用羊水中高浓度非磷酸化IGFBP-1诊断胎膜早破,测定宫颈分泌物中的磷酸化IGFBP-1预测分娩。
作者 贺贞
出处 《国外医学(妇产科学分册)》 2002年第2期73-76,共4页 Foreign Medical Sciences(Obstet Gynecol Fascicle)
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