摘要
妊娠小白鼠58只随机分组,至孕第7～11天给实验组孕鼠每天分别以500mg/kg(水蛭1组)及1000mg/kg(水蛭2组)的中药水蛭煎剂灌胃,至孕第18天记录各组的孕鼠和胎鼠体重,死胎、吸收胎及堕胎数。结果:水蛭1、2两组胎鼠体重下降,致畸作用显著,死胎、吸收胎比例升高;水蛭2组孕鼠体重下降,堕胎作用显著,与对照组比较,差异均有非常显著意义(P<0.01)。
58 pregnant mice were divided into several groups at random. 500 mg/kg(Group I ) and 1,000mg/kg (Group II) decoctioa of Whitmania pigra were daily perfused into the stomach of the experimental groups on the 7th to the 11th day after pregnancy The body weight and the number of dead embryos, absorbed embryos and abortion of the pregnant mice of different groups were recorded on the 18th day after pregnancy. The results were as follows. The reduction of the body weight and the teratogenic effects on the pregnant mice in Group I and Group II were remarkable. The percentage of the dead embryos and the absorbed embryos were increased. In the Group II the body weight of the pregnant mice was reduced and the abortive effect was obvious. As compared with the control group, the difference was very significant ( P<0.01 ) .
出处
《温州医学院学报》
CAS
1991年第3期139-141,共3页
Journal of Wenzhou Medical College
关键词
水蛭
胚胎
发育
致畸作用
N, N' -methylene- bis (2-amino-1, 3,4 thiadiazole)
Whitmania pigra
embryo
abortion
teratogenic effect
