摘要
目的 :制备黄芪多糖 (PAM)硫酸酯 ,寻找具有优良抗病毒活性的物质。方法 :将纯化得到的 PAM,用硫酸化试剂氯磺酸 -吡啶合成 PAM硫酸酯 (PAMS) ,采用体外抗病毒试验测定了 PAMS对 I型单纯疱疹病毒HSV-1的活性。结果 :制备了 PAMS,在抑制 HSV-1活性的试验中给药组与对照组 (阿昔洛韦 ,ACV)之间有非常显著的差异。结论 :PAMS有很强的抑制 型单纯疱疹病毒的活性 ,在相同浓度下 ,优于 ACV。
AIM The purpose is to prepare \%Astragalus mongholicus\% Bunge polysaccharide sulfate (PAMS), and to search for the substance with high antivirus activity. METHODS PAM was obtained by reaction of purified \%Astragalus mongholicus\% Bunge polysaccharide (PAM) with chlorosulfonic acid pyridine. The activity of PAMS was determinated by antiviral study \%in vitro\% on HSV 1. RESULTS There was very significant difference between the activities of PAMS and control acyclovir(ACV )on HSV 1. CONCLUSION PAM has shown higher activity on HSV 1 than that of ACV at the same concentration.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2002年第2期146-148,共3页
Journal of China Pharmaceutical University
关键词
多糖硫酸酯
合成
体外
抗病毒
黄芪
Polysaccharide sulfate
Synthesis
Antiviral study
\%In vitro\%
\%Astragalus mongholicus\%
