摘要
研究胃癌组织中MV计数 ,p53蛋白表达及其相互关系。方法 :胃癌组织中常规石蜡包埋切片 ,切片行常规ABC免疫组化染色。结果 :高分化、未淋巴结转移或未远处器官转移病例MV计数和 p53蛋白阳性率均明显低于低或未分化、淋巴结转移或远处器官转移病例 ;p53蛋白阳性病例MV计数明显高于p53蛋白阴性病例。结论 :MV计数和 p53蛋白表达可能是反映胃癌生物学行为、转移发生及预后的重要参数 ;p53蛋白具有促进胃癌MV生成 。
Objective:To study the counts of microvessels and the expressions of p53 oncoprotein and their relationship in gastric cancer tissue.Methods:The specimens of gastric cancer tissues were routinely embeded in paraffin and cut in sections,and the sections were stained by routine immunohistochemical method of avidin-biotin complex.Results:The counts of microvessels and the positive rates of p53 oncoprotein were significantly lower in the cases of well-differentiation, without metastasis of lymphnode or distant organs than those in the ones of poor differentiation or undifferentiation, with metastasis of lymphnode or distant organs.The counts of microvessels were significantly higher in the positive cases of p53 oncoprotein than that in the negative ones of p53 oncoprotein.Conclusions:The counts of microvessels and the expressions of p53 oncoprotein might be important markers in reflecting biological behaviors,metastatic states and prognosis of gastric cancer. The p53 oncoprotein might promote the angiogenesis of gastric cancer tissue and be an important regulating factor of angiogenesis.
出处
《中国现代医学杂志》
CAS
CSCD
2002年第5期3-5,共3页
China Journal of Modern Medicine
基金
受国家自然科学基金资助 (编号 394 0 0 12 7)
