摘要
研究了 2 -氯 -4 -硝基苯胺、4-氯 -3 -硝基苯胺、2 -氯 -5 -硝基苯胺、2 ,4-二氯苯胺、3 ,4-二氯苯胺、2 ,5 -二氯苯胺、2 ,3 -二氯苯胺对斑马鱼 (Brachydaniorerio)的 96h急性毒性 ,96hLC50 分别为 6 99,2 5 8,8 63 ,7 79,6 0 8,5 2 3 ,0 49mg L。运用三维定量结构活性相关模型(3D -QSAR)对这些化合物的毒性效应和构效关系进行了分析和评价 ,估算毒性值与实际观测值相关性较好 ,相关系数R2 =0 90
The acute toxicities of 7 chloroanilines,i.e.2-chloro-4-nitroaniline,4-chloro-3-nitroaniline,2-chloro-5-nitroaniline,2,4-dichloroaniline,3,4-dichloroaniline,2,5-dichloroaniline and 2,3-dichloroaniline,to zebra fish ( Brachydanio rerio) were studied,and the 96 h LC 50 were 6\^99,2\^58,8\^63,7\^79,6\^08,5\^23 and 0 49 mg/L respectively.3D-QSAR analysis of these chemicals was conducted to study the relationship between molecular structure and biological activity (toxicity),and the observed values were well correlated with the calculated ( R\+2 =0 907).
出处
《环境科学研究》
EI
CAS
CSCD
北大核心
2002年第2期6-7,11,共3页
Research of Environmental Sciences
基金
国家自然科学基金资助项目 (3 9770 15 3 )
