摘要
目的 探讨p2 7及Ki 6 7联合检测对于良、恶性甲状腺滤泡状肿瘤的鉴别价值。方法 采用S -P免疫组化法检测 5 3例甲状腺滤泡状肿瘤 (滤泡状腺瘤 2 0例 ,滤泡状腺癌 33例 )p2 7和Ki 6 7的表达指数 (LI)。结果 p2 7蛋白水平在正常甲状腺组织表达最高 ,滤泡状腺瘤次之 ,滤泡状腺癌最低 ;而Ki 6 7在正常甲状腺组织几乎不表达 (LI <0 .0 1% ) ,滤泡状腺癌最高 ,滤泡状腺瘤次之。滤泡状腺瘤与腺癌的 p2 7和Ki 6 7标记指数相比较差异有显著性意义 ( P <0 .0 0 1) ,p2 7在甲状腺滤泡状腺瘤、腺癌两类的最佳分界值为LI =2 8.3;Ki 6 7的最佳分界值为LI =10 .85。结论 p2 7和Ki 6 7的检测可有效地区别良、恶性甲状腺滤泡状肿瘤 ,也有助于术前甲状腺针吸细胞学对滤泡状腺癌的诊断。
Objective To study the value of p27 and Ki-67 detection in differentiating benign from malignant thyroid follicular neoplasms. Methods Labelling index (LI) of thyroid neoplasms from thyroidectomy specimens were detected immunohistochemically Results The normal thyroid group had the highest expression of p27 , and the lowest expression of Ki-67. There was significant difference in the expressions of p27 and Ki-67 between follicular thyroid adenomas (FA) and follicular thyroid cancers (FTC) (P<0.001).The optimal cutpoint of FA and FTC in p27 was 28.3,in Ki-67 was 10.85. Conclusions p27 and Ki-67 detection may be effective in distinguishing FA from FTC in difficult diagnostic cases, and useful as an aid in the preoperative diagnosis of FTC from fine needle aspiration cytology.
出处
《中国普通外科杂志》
CAS
CSCD
2002年第5期289-292,共4页
China Journal of General Surgery
