摘要
以无水三氯化铝作催化剂 ,间二氟苯与氯乙酰氯反应合成 2 -氯 - 2′,4′-二氟苯乙酮。通过正交设计对其合成条件进行探讨 ,筛选出最佳合成条件。反应收率明显提高 ,可达 90 %以上。
A new process has been developed to synthesize 2 chloro 2′,4′ difluorophenethyl keton from benzene m difluoride and chloro acetic chloride by catalysis of aluminium trichloride, the optimum reaction conditions have been found by orthogonal experimental design, the production rate was over 90%.
出处
《太原理工大学学报》
CAS
2002年第3期309-311,共3页
Journal of Taiyuan University of Technology
