摘要
目的 初步探讨彩色视觉诱发电位 (visualevokedpotential,VEP)检查在临床应用的可行性 ,为临床诊断色觉异常提供新的方法。方法 应用计算机软件技术 ,制作 4种翻转棋盘格作为视觉刺激模式 ,包括黑 白翻转棋盘格 (对比度为 95 % )和等亮度红 白、绿 白和红 绿翻转棋盘格 (饱和度为 10 0 % )。棋盘格大小为 2 5′视角 ,翻转频率为 0 8Hz。用多导程视觉电生理记录仪记录正常组 30例色觉正常者和异常组 13例先天性色觉异常者 4种视觉刺激模式的瞬态VEP图形。结果 正常组4种视觉刺激模式VEPP1波潜伏期由短至长依次为红 白、黑 白、红 绿和绿 白 ,差异有非常显著意义(P <0 0 1) ;VEPP1波振幅由高至低依次为黑 白、红 白、红 绿、绿 白 ,差异有显著意义 (P <0 0 5 ) ,其中红 白、红 绿、绿 白 3种视觉刺激模式间VEPP1波振幅比较 ,差异无显著意义 (P >0 0 5 )。异常组VEPP1波潜伏期和振幅 4种视觉刺激模式比较 ,差异均无显著意义 (P >0 0 5 ) ,其中以黑 白翻转棋盘格刺激模式的潜伏期最短 ;红绿色盲和绿色盲患者对绿 白翻转棋盘格刺激无反应。正常组与异常组VEPP1波比较 ,4种视觉刺激模式的潜伏期差异均无显著意义 (P >0 0 5 ) ;黑 白翻转棋盘格刺激模式的振幅差异无显著意义 (P >0 0 5 ) 。
Objective To understand the specific nature of the color and brightness components of the human visual evoked potential and explore the possibility of an objective method for examining the color vision Method The transient VEP was measured in normal subjects and persons with deficient color vision by multichannel electro physiological apparatus In the experiment, four kinds of reversal checkerboard patterns are simulated by the computer software technology as stimuli The patterns included black white (95% contrast), isoluminance chromatic checkerboards red white, green white, red green (100% saturation), which were 25′ in visual angle and alternated at a rate of 0 8 Hz The main component, P 1 wave, was analyzed Results (1) The normal subject group: The P 1 latencies in four conditions were obtained in terms of the length of latencies, the ordinal of P 1 latencies (from short to long) was as follows: red white <black white <red green <green white There were very significant differences among the four latencies ( P <0 01) The P 1 amplitudes elicited with the black white were higher than those with chromatic ones But among the P 1 amplitudes elicited with chromatic checkerboards there were no difference (2) The group with deficient color vision: There were no significant differences in the P 1 latencies and amplitudes elicited with the four stimuli The length of latencies with black white stimulus was the shortest Red green blindness as well as deuteranopia had no response to green stimulus but did to red or red green stimulus (3) Between the two groups, there were no differences in the P 1 latencies, but the P 1 amplitudes of persons with deficient color vision elicited with the chromatic stimuli were obviously lower Conclusion The results show that it is feasible to use chromatic VEP for examining congenital color vision deficiency, especially for red green blindness and deuteranopia At present, there is lack of quantitative and qualitative results of color VEP examination
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2002年第6期355-359,共5页
Chinese Journal of Ophthalmology
关键词
视觉诱发电位
色觉缺陷
研究
计算机辅助诊断
Evoked potentials, visual
Color vision defects
Research
Diagnosis, computer assisted
