摘要
目的探讨饮酒对血压及血浆皮质醇水平的影响及其可能机制。方法随机选取 10 0例中年男性 ,根据饮酒情况分为饮酒暴露组(n=80 )及非暴露组 (n=2 0 ) ,测定血压及血浆皮质醇水平并进行相关分析。结果与饮酒非暴露组比较 ,饮酒暴露组动脉血压及血浆皮质醇水平升高 (P<0 .0 1) ;每日饮酒量愈大、饮酒年限愈长 ,血压及血浆皮质醇水平升高愈明显 (P<0 .0 1) ;饮酒者的血浆皮质醇水平与收缩压和舒张压水平呈明显正相关 (分别是 r=0 .49,P<0 .0 1;r=0 .47,P<0 .0 1)。结论饮酒者可能通过乙醇抑制 11β羟化固醇脱氢酶 2型的催化活性 ,致使血浆皮质醇水平升高诱导高血压。
Objective To study the effect of alcohol on blood pressure and the levels of plasma cortisol and its possible mechanism.Methods 100 middle aged men were divided into alcohol consumption group(n=80) and control group (n=20) .Their blood pressure and plasma cortisol level were determined.Relative analysis was made between blood pressure and plasma cortisol level.Results Compared with control group,blood pressure and cortisol level were significantly increased in alcohol consumption group (P<0.01).The more alcohol taken everyday and the longer the years for taking alcohol,the more obviously the blood pressure and plasma cortisol level were increased (P<0.01).The level of plasma cortisol was positively correlated with systolic blood pressure and diastolic blood pressure(r= 0.49 ,P<0.01;r=0.47,P<0.01,respectively).Conclusion Alcohol may induce hypertension because of increased level of plasma cortisol which is caused by inhibition of the enzyme of 11β hydroxysteroid dehydrogenase type Ⅱ.
出处
《中国综合临床》
北大核心
2002年第6期511-512,共2页
Clinical Medicine of China
