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都梁软胶囊的药效及毒性试验 被引量:14

Tests of the pharmacodynamics and toxicity of Duliang capsule
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摘要 目的观察都梁软胶囊和都梁丸的镇痛作用、对血瘀动物模型血流动力学的影响及毒性作用。方法在小鼠热板和扭体反应模型上,观察用药后舔足潜伏期和扭体数的改变;采用LG-R80全自动血液粘度测试仪测定血瘀大鼠模型全血、血浆的粘度变化;并行急性毒性及长期毒性观察。结果都梁丸5 g/kg·b.w.及都梁软胶囊10、5、3 g/kg·b.w.均能减少醋酸致小鼠扭体次数,并延长小鼠舔足潜伏期。服用都梁软胶囊0.5 h后即可出现止痛作用,而都梁丸则在服用1 h后才能观察到止痛作用。都梁软胶囊和都梁丸均能降低血瘀大鼠的全血粘度及红细胞压积;急性毒性及长期毒性实验未发现药物毒性反应。结论无论是胶囊还是丸剂均有明显的止痛、降低血瘀大鼠的全血粘度及红细胞压积作用,但都梁软胶囊在止痛方面起效快,且临床应用有效、安全。 Objective To study the analgesic efficacy, toxicity and impact of Duliang capsule (DLC) and Duliang pill (DLP), different dosage forms of a patent Chinese herbal medicine, on the hemodynamics in mice and rats. Methods In hotplate and writhing tests in mice, the effects of both drugs on the latency of paw-licking response and the writhing number of times were observed. The changes of blood viscosity in rat models of blood stasis were measured with Viscometer-R80, and acute and chronic toxicity of DLC observed. Results DLP at the dose of 5 g/kg·b.w. and DLC at 10, 5 or 3 g/kg·b.w. significantly prolonged the latency of paw-licking response and reduced writhing times. The analgesic effects of DLC and DLP occurred 0.5 and 1 h respectively after the administration, and they could both lower the viscosity of the whole blood and hematocrit level in the blood-stasis rat models. Toxicity of the drug was not observed in acute or chronic toxicity tests. Conclusions Both DLC and DLP possess strong analgesic effect and can lower blood viscosity and hematocrit, but DLC takes effect sooner than DLP as analgesics and can be effectively and safely applied clinically.
出处 《第一军医大学学报》 CSCD 北大核心 2002年第6期561-563,共3页 Journal of First Military Medical University
关键词 都梁软胶囊 药效 毒性试验 都梁丸 止痛作用 血流动力学 中成药 Duliang capsule Duliang pill analgesic action hemodynamics toxicity Chinese herbal medicine
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参考文献3

  • 1魏玉平,刘俊,颜小林,姚欣,郑成贵,陈前进,田立武.都梁丸提取工艺研究[J].中草药,2000,31(5):349-350. 被引量:18
  • 2赵明敏 徐叔云 等.镇痛药物实验法.药理实验方法学[M].北京:人民卫生出版社,1994.695-700.
  • 3毛藤敏 陈奇 等.血液流变性.中药药理实验方法学[M].北京:人民卫生出版社,1993.564-6.

二级参考文献4

  • 1.中华人民共和国药典(一)[M].,1995.87.
  • 2姚新生.天然药物化学(第二版)[M].北京:人民卫生出版社,1997.191-236.
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  • 4中华人民共和国药典委员会,中华人民共和国药典.一部,1995年,87页

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